Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts (Q33730171)

29 July 2017

title

Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts (English)

1 reference

29 July 2017

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James P Allison

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Jelena Vider

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Nicholas P Restifo

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Sergio A Quezada

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Taha Merghoub

1 reference

29 July 2017

Tyler R Simpson

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29 July 2017

Karl S Peggs

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29 July 2017

Xiaozhou Fan

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29 July 2017

Ronald Blasberg

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29 July 2017

Hideo Yagita

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29 July 2017

Pawel Muranski

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29 July 2017

Paul A Antony

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29 July 2017

language of work or name

English

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publication date

15 February 2010

1 reference

Journal of Experimental Medicine

29 July 2017

published in

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29 July 2017

volume

207

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29 July 2017

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29 July 2017

page(s)

637-650

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Lack of specific gamma-retroviral vector long terminal repeat promoter silencing in patients receiving genetically engineered lymphocytes and activation upon lymphocyte restimulation

29 July 2017

cites work

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Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies

14 July 2018

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Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

14 July 2018

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Self-antigen-specific CD8+ T cell precursor frequency determines the quality of the antitumor immune response.

14 July 2018

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14 July 2018

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Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells.

14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens

14 July 2018

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Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma

14 July 2018

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Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1

14 July 2018

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Tumor-specific Th17-polarized cells eradicate large established melanoma

14 July 2018

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Increased competition for antigen during priming negatively impacts the generation of memory CD4 T cells

14 July 2018

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14 July 2018

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CD4 cells can be more efficient at tumor rejection than CD8 cells

14 July 2018

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Induced sensitization of tumor stroma leads to eradication of established cancer by T cells

14 July 2018

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CD4+ T cells cooperate with macrophages for specific elimination of MHC class II-negative cancer cells

14 July 2018

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Increased intensity lymphodepletion and adoptive immunotherapy--how far can we go?

14 July 2018

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14 July 2018

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CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells

14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

14 July 2018

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Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor

14 July 2018

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Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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Transcriptional regulation of the MHC II gene DRA in untransformed human thyrocytes

14 July 2018

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CD4(+) T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-gamma

14 July 2018

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The central role of CD4(+) T cells in the antitumor immune response

14 July 2018

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Cellular responses to interferon-gamma

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839156

Regulation of transcription of MHC class II genes

14 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839156

Therapy of disseminated murine leukemia with cyclophosphamide and immune Lyt-1+,2- T cells. Tumor eradication does not require participation of cytotoxic T cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2839156

Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia

14 July 2018

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Crossref

https://api.crossref.org/works/10.1084%2FJEM.20091918

Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer.

21 January 2018

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Crossref

https://api.crossref.org/works/10.1084%2FJEM.20091918

Bystander elimination of antigen loss variants in established tumors

21 January 2018

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https://api.crossref.org/works/10.1084%2FJEM.20091918

Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication.

21 January 2018

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Eradication of established tumors by CD8+ T cell adoptive immunotherapy

30 October 2018

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12 December 2020

The Balance Between Donor T Cell Anergy and Suppression Versus Lethal Graft-Versus-Host Disease Is Determined by Host Conditioning

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12 December 2020

The role of CD4+ T cell responses in antitumor immunity

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12 December 2020

HLA-DMB expression by thyrocytes: indication of the antigen-processing and possible presenting capability of thyroid cells

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12 December 2020

Identifiers

DOI

10.1084/JEM.20091918

1 reference

29 July 2017

1 reference

29 July 2017

1 reference