C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production (Q33601747)

28 July 2017

title

C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production (English)

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28 July 2017

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Deborah A Fraser

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28 July 2017

Karntipa Pisalyaput

series ordinal

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28 July 2017

Andrea J Tenner

series ordinal

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28 July 2017

language of work or name

English

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publication date

16 November 2009

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Journal of Neurochemistry

28 July 2017

published in

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28 July 2017

volume

112

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28 July 2017

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28 July 2017

page(s)

733-743

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C1q differentially modulates phagocytosis and cytokine responses during ingestion of apoptotic cells by human monocytes, macrophages, and dendritic cells.

28 July 2017

cites work

1 reference

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Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease

21 June 2018

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IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells

21 June 2018

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21 June 2018

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C1q: the perfect complement for a synaptic feast?

21 June 2018

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21 June 2018

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The complement protein properdin binds apoptotic T cells and promotes complement activation and phagocytosis.

21 June 2018

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Directing an appropriate immune response: the role of defense collagens and other soluble pattern recognition molecules

21 June 2018

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C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition

21 June 2018

1 reference

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The classical complement cascade mediates CNS synapse elimination

21 June 2018

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Engulfment of apoptotic cells: signals for a good meal

21 June 2018

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Role of complement and complement regulators in the removal of apoptotic cells.

21 June 2018

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Generation of inhibitory NFkappaB complexes and phosphorylated cAMP response element-binding protein correlates with the anti-inflammatory activity of complement protein C1q in human monocytes

21 June 2018

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The double-edged flower: roles of complement protein C1q in neurodegenerative diseases

21 June 2018

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Role of complement and other innate immune mechanisms in the removal of apoptotic cells

21 June 2018

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CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells

21 June 2018

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Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.

21 June 2018

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C1q, autoimmunity and apoptosis

21 June 2018

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Phagocytotic removal of apoptotic, inflammatory lymphocytes in the central nervous system by microglia and its functional implications

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Complement component C1q modulates the phagocytosis of Abeta by microglia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

C1q acts synergistically with phorbol dibutyrate to activate CR1-mediated phagocytosis by human mononuclear phagocytes.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

C1q and MBL, components of the innate immune system, influence monocyte cytokine expression.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Macrophage colony stimulatory factor and interferon-gamma trigger distinct mechanisms for augmentation of beta-amyloid-induced microglia-mediated neurotoxicity

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Microglial activation and increased synthesis of complement component C1q precedes blood-brain barrier dysfunction in rats

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Apoptotic PC12 cells exposing phosphatidylserine promote the production of anti-inflammatory and neuroprotective molecules by microglial cells.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Amyloid beta plaque-associated proteins C1q and SAP enhance the Abeta1-42 peptide-induced cytokine secretion by adult human microglia in vitro.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Predominant role of IgM-dependent activation of the classical pathway in the clearance of dying cells by murine bone marrow-derived macrophagesin vitro

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2809134

Enhancement of macrophage phagocytosis upon iC3b deposition on apoptotic cells

30 October 2018

1 reference

12 December 2020

Amyloid beta protein primes cultured rat microglial cells for an enhanced phorbol 12-myristate 13-acetate-induced respiratory burst activity

1 reference

12 December 2020

C4b-binding Protein and Factor H Compensate for the Loss of Membrane-bound Complement Inhibitors to Protect Apoptotic Cells against Excessive Complement Attack

1 reference

12 December 2020

C4b-binding protein in Alzheimer's disease: Binding to Aβ1–42 and to dead cells

1 reference

12 December 2020

The globular heads of C1q specifically recognize surface blebs of apoptotic vascular endothelial cells

1 reference

12 December 2020

Direct binding of C1q to apoptotic cells and cell blebs induces complement activation

1 reference

12 December 2020

Opsonization with C1q and mannose-binding lectin targets apoptotic cells to dendritic cells

1 reference

12 December 2020

Chronically stimulated microglial cells do no longer alter their immune functions in response to the phagocytosis of apoptotic cells

1 reference

12 December 2020

Microglial release of nitric oxide by the synergistic action of beta-amyloid and IFN-gamma

1 reference

12 December 2020

C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited

1 reference

12 December 2020

10.1111/J.1471-4159.2009.06494.X

Identifiers

DOI

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28 July 2017

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28 July 2017

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