Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor (Q33597663)

28 July 2017

title

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor (English)

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28 July 2017

1 reference

Marina Konopleva

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28 July 2017

Matthew R Janes

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28 July 2017

Jose J Limon

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28 July 2017

Lomon So

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28 July 2017

Jing Chen

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28 July 2017

Raymond J Lim

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28 July 2017

Melissa A Chavez

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28 July 2017

Collin Vu

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28 July 2017

Michael B Lilly

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28 July 2017

Sharmila Mallya

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28 July 2017

S Tiong Ong

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28 July 2017

Michael B Martin

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28 July 2017

Pingda Ren

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28 July 2017

Yi Liu

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28 July 2017

Christian Rommel

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28 July 2017

David A Fruman

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28 July 2017

language of work or name

English

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publication date

13 January 2010

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28 July 2017

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28 July 2017

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28 July 2017

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28 July 2017

page(s)

205-213

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Regulation of the mTOR signaling pathway: from laboratory bench to bedside and back again

28 July 2017

cites work

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The dual PI3K/mTOR inhibitor PI-103 promotes immunosuppression, in vivo tumor growth and increases survival of sorafenib-treated melanoma cells.

21 June 2018

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The cunning little vixen: Foxo and the cycle of life and death

21 June 2018

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Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin

21 June 2018

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The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment

21 June 2018

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A kinase-dead knock-in mutation in mTOR leads to early embryonic lethality and is dispensable for the immune system in heterozygous mice

21 June 2018

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Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

21 June 2018

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PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers

21 June 2018

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21 June 2018

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Impact of tyrosine kinase inhibitors on patient outcomes in Philadelphia chromosome-positive acute lymphoblastic leukaemia

21 June 2018

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The emerging safety profile of mTOR inhibitors, a novel class of anticancer agents

21 June 2018

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Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia

21 June 2018

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Fine tuning the immune response with PI3K.

21 June 2018

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

21 June 2018

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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

21 June 2018

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Translation of the Philadelphia chromosome into therapy for CML.

21 June 2018

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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

21 June 2018

1 reference

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

21 June 2018

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Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

21 June 2018

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Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises

21 June 2018

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Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells

21 June 2018

1 reference

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Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance

21 June 2018

1 reference

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Investigating human leukemogenesis: from cell lines to in vivo models of human leukemia

21 June 2018

1 reference

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

21 June 2018

1 reference

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Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy.

21 June 2018

1 reference

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Dynamic FoxO transcription factors

21 June 2018

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Defining the role of mTOR in cancer

21 June 2018

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AKT/PKB signaling: navigating downstream

21 June 2018

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Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

21 June 2018

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Dasatinib (BMS-354825) pharmacokinetics and pharmacodynamic biomarkers in animal models predict optimal clinical exposure

21 June 2018

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Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice.

21 June 2018

1 reference

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A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation.

21 June 2018

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"Oncogenic shock": explaining oncogene addiction through differential signal attenuation

21 June 2018

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

21 June 2018

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Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias

21 June 2018

1 reference

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017764

Oncogenic PI3K and its role in cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017764

Involvement of the phosphoinositide 3-kinase/Akt signaling pathway in the resistance to therapeutic treatments of human leukemias

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017764

Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017764

The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017764

Immune regulation by rapamycin: moving beyond T cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017764

The pharmacology of mTOR inhibition

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017764

TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017764

PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017764

The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017764

Treating imatinib-resistant leukemia: the next generation targeted therapies.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4017764

Mammalian target of rapamycin as a therapeutic target in oncology

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20072130

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NM.2091

1 reference

28 July 2017

1 reference

28 July 2017

1 reference