Analysis of siRNA specificity on targets with double-nucleotide mismatches (Q33329034)

25 July 2017

title

Analysis of siRNA specificity on targets with double-nucleotide mismatches (English)

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25 July 2017

Gunnar Norstedt

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Cecilia Dahlgren

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25 July 2017

Hong-Yan Zhang

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25 July 2017

Quan Du

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25 July 2017

Maria Grahn

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25 July 2017

Claes Wahlestedt

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25 July 2017

Zicai Liang

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25 July 2017

language of work or name

English

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publication date

17 April 2008

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25 July 2017

published in

Nucleic Acids Research

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25 July 2017

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25 July 2017

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25 July 2017

page(s)

e53

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Progress and prospects: RNA-based therapies for treatment of HIV infection.

25 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

Designing siRNA that distinguish between genes that differ by a single nucleotide

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

No induction of anti-viral responses in human cell lines HeLa and MCF-7 when transfecting with siRNA or siLNA.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

A computational study of off-target effects of RNA interference

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

Modulation of angiogenesis with siRNA inhibitors for novel therapeutics

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

Single processing center models for human Dicer and bacterial RNase III

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

Rational siRNA design for RNA interference

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

Functional siRNAs and miRNAs Exhibit Strand Bias

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

RNA interference is mediated by 21- and 22-nucleotide RNAs

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

Applications of RNA interference: current state and prospects for siRNA-based strategies in vivo

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

Mismatched siRNAs downregulate mRNAs as a function of target site location.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs).

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

Asymmetry in the assembly of the RNAi enzyme complex

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

Expression profiling reveals off-target gene regulation by RNAi

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

Tolerance for mutations and chemical modifications in a siRNA.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2396434

Validating siRNA using a reporter made from synthetic DNA oligonucleotides

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18420656

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKN190

1 reference

25 July 2017

1 reference

25 July 2017

1 reference