PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. (Q33306700)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18030348%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

title

PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis (English)

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27 December 2019

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27 December 2019

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27 December 2019

Pazit Polak

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27 December 2019

Man Lyang Kim

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27 December 2019

Klaus D Molle

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27 December 2019

Adiel Cohen

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27 December 2019

Paul Jenö

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27 December 2019

Michael N Hall

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27 December 2019

language of work or name

English

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publication date

21 November 2007

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27 December 2019

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27 December 2019

volume

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issue

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27 December 2019

page(s)

e1217

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Creative Commons Attribution 4.0 International

27 December 2019

start time

21 November 2007

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April 2022 Public Data File from Crossref

copyrighted

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cites work

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

1 reference

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

21 June 2018

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

21 June 2018

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TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

21 June 2018

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21 June 2018

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Effects of a combined treatment with mTOR inhibitor RAD001 and tamoxifen in vitro on growth and apoptosis of human cancer cells

21 June 2018

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The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL

21 June 2018

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Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

21 June 2018

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Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis.

21 June 2018

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STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx

21 June 2018

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Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways

21 June 2018

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21 June 2018

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21 June 2018

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 June 2018

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21 June 2018

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 June 2018

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21 June 2018

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MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding

21 June 2018

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21 June 2018

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

21 June 2018

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

21 June 2018

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21 June 2018

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21 June 2018

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Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

21 June 2018

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Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 June 2018

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 June 2018

1 reference

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075366

Expression and disruption of the Arabidopsis TOR (target of rapamycin) gene

21 June 2018

1 reference

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TNF-alpha--accelerated apoptosis abrogates ANCA-mediated neutrophil respiratory burst by a caspase-dependent mechanism

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075366

Mammalian TOR: a homeostatic ATP sensor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075366

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075366

Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075366

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075366

The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075366

The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075366

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

21 June 2018

1 reference

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A mammalian protein targeted by G1-arresting rapamycin-receptor complex

21 June 2018

1 reference

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RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075366

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2075366

TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation

21 June 2018

1 reference

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PRR5 encodes a conserved proline-rich protein predominant in kidney: analysis of genomic organization, expression, and mutation status in breast and colorectal carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0001217

An activated mTOR mutant supports growth factor-independent, nutrient-dependent cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0001217

Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0001217

The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0001217

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0001217

Automated identification of amino acid sequence variations in proteins by HPLC/microspray tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0001217

10.1371/JOURNAL.PONE.0001217

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18030348%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18030348%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

PubMed publication ID

18030348

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18030348%20AND%20SRC:MED&resulttype=core&format=json