ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery (Q33292088)

25 July 2017

title

ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery (English)

1 reference

25 July 2017

Annapaola Franchitto

0 references

Pietro Pichierri

0 references

Francesca Ammazzalorso

series ordinal

1 reference

25 July 2017

Livia Maria Pirzio

series ordinal

1 reference

25 July 2017

Margherita Bignami

series ordinal

1 reference

25 July 2017

language of work or name

English

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publication date

27 August 2010

1 reference

25 July 2017

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25 July 2017

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25 July 2017

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25 July 2017

page(s)

3156-3169

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Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.

25 July 2017

cites work

1 reference

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ATR/Mec1: coordinating fork stability and repair.

21 June 2018

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Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance

21 June 2018

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Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway

21 June 2018

1 reference

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The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis

21 June 2018

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Roles of the Werner syndrome RecQ helicase in DNA replication

21 June 2018

1 reference

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ATR: an essential regulator of genome integrity

21 June 2018

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An oncogene-induced DNA damage model for cancer development

21 June 2018

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Phosphorylation-dependent interactions of BLM and 53BP1 are required for their anti-recombinogenic roles during homologous recombination

21 June 2018

1 reference

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Interplay between wrn and the checkpoint in s-phase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944071

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944071

Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944071

The Werner and Bloom syndrome proteins catalyze regression of a model replication fork

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944071

Common fragile sites as targets for chromosome rearrangements

21 June 2018

1 reference

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ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks

21 June 2018

1 reference

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Mechanisms of common fragile site instability.

21 June 2018

1 reference

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Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944071

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

21 June 2018

1 reference

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Chk1-dependent S-M checkpoint delay in vertebrate cells is linked to maintenance of viable replication structures.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944071

Werner syndrome protein and the MRE11 complex are involved in a common pathway of replication fork recovery

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944071

Biochemical and kinetic characterization of the DNA helicase and exonuclease activities of werner syndrome protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944071

Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest

21 June 2018

1 reference

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Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM(-/-) and c-Abl(-/-) cells

21 June 2018

1 reference

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Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944071

ATR Regulates Fragile Site Stability

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944071

Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944071

Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944071

Werner syndrome cells are sensitive to DNA cross-linking drugs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944071

DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944071

Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944071

ATM-dependent phosphorylation and accumulation of endogenous BLM protein in response to ionizing radiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944071

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944071

The controlling role of ATM in homologous recombinational repair of DNA damage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944071

Substrate specificities and identification of putative substrates of ATM kinase family members

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944071

Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944071

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2944071

ATR and H2AX cooperate in maintaining genome stability under replication stress

21 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.205

Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.205

The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.205

Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.205

Visualization of altered replication dynamics after DNA damage in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.205

Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.205

Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.205

Werner syndrome helicase activity is essential in maintaining fragile site stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.205

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.205

Werner syndrome protein contains three structure-specific DNA binding domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2010.205

Biochemical characterization of the DNA substrate specificity of Werner syndrome helicase

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20802463

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

DNA double-strand breaks measured in individual cells subjected to gel electrophoresis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20802463

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/EMBOJ.2010.205

1 reference

25 July 2017

1 reference

25 July 2017

1 reference