Selection, design, and characterization of a new potentially therapeutic ribozyme (Q32067536)

6 July 2017

title

Selection, design, and characterization of a new potentially therapeutic ribozyme (English)

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6 July 2017

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Alex Burgin

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6 July 2017

Shawn P Zinnen

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6 July 2017

Kristal Domenico

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6 July 2017

Mike Wilson

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6 July 2017

Brent A Dickinson

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6 July 2017

Amber Beaudry

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6 July 2017

Victor Mokler

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6 July 2017

Andrew T Daniher

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6 July 2017

Leonid Beigelman

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6 July 2017

language of work or name

English

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publication date

1 February 2002

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6 July 2017

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6 July 2017

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6 July 2017

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6 July 2017

page(s)

214-228

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RNA cleavage by a DNA enzyme with extended chemical functionality

6 July 2017

cites work

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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In vitro selection of a novel nuclease-resistant RNA phosphodiesterase

21 June 2018

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Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA.

21 June 2018

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Transient transfection of a synthetic hammerhead ribozyme targeted against human MGMT gene to cells in culture potentiates the genotoxicity of the alkylation damage induced by mitozolomide

21 June 2018

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A small catalytic RNA motif with Diels-Alderase activity.

21 June 2018

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Efficient synthesis of nucleic acids heavily modified with non-canonical ribose 2'-groups using a mutantT7 RNA polymerase (RNAP).

21 June 2018

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21 June 2018

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The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone

21 June 2018

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21 June 2018

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The joys of in vitro selection: chemically dressing oligonucleotides to satiate protein targets

21 June 2018

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A nuclease-resistant protein kinase C alpha ribozyme blocks glioma cell growth

21 June 2018

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An amino acid as a cofactor for a catalytic polynucleotide

21 June 2018

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In vitro selection of a purine nucleotide-specific hammerheadlike ribozyme

21 June 2018

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A DNA enzyme with Mg(2+)-dependent RNA phosphoesterase activity

21 June 2018

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A DNA enzyme that cleaves RNA

21 June 2018

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The structure, function and application of the hammerhead ribozyme

21 June 2018

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A general purpose RNA-cleaving DNA enzyme

21 June 2018

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Optimizing the cell efficacy of synthetic ribozymes. Site selection and chemical modifications of ribozymes targeting the proto-oncogene c-myb

21 June 2018

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Kinetic characterization of two I/II format hammerhead ribozymes

21 June 2018

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Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets

21 June 2018

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21 June 2018

Ribonucleosides and RNA.

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Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B.

21 June 2018

1 reference

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A mutant T7 RNA polymerase as a DNA polymerase.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1370244

Selection of novel Mg(2+)-dependent self-cleaving ribozymes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1370244

Synthesis, deprotection, analysis and purification of RNA and ribozymes

21 June 2018

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Improved predictions of secondary structures for RNA

21 June 2018

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Function of specific 2'-hydroxyl groups of guanosines in a hammerhead ribozyme probed by 2' modifications

21 June 2018

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A comparison of optimal and suboptimal RNA secondary structures predicted by free energy minimization with structures determined by phylogenetic comparison

21 June 2018

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17 Predicting optimal and suboptimal secondary structure for RNA

21 June 2018

1 reference

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Regulation of cell magnesium

21 June 2018

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In vitro evolution of the hammerhead ribozyme to a purine-specific ribozyme using mutagenic PCR with two nucleotide analogues

21 June 2018

1 reference

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Pharmacokinetics and tissue distribution of a ribozyme directed against hepatitis C virus RNA following subcutaneous or intravenous administration in mice

31 October 2018

1 reference

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Ribozyme inhibition of the protein kinase C alpha triggers apoptosis in glioma cells

31 October 2018

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Antitumor and antimetastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors

31 October 2018

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12 December 2020

Improved parameters for prediction of RNA structure

1 reference

12 December 2020

Kinetic Characterization of Ribonuclease-Resistant 2′-Modified Hammerhead Ribozymes

1 reference

12 December 2020

Study of a hammerhead ribozyme containing 2'-modified adenosine residues

1 reference

12 December 2020

Minimum ribonucleotide requirement for catalysis by the RNA hammerhead domain

1 reference

12 December 2020

Toxicity, metabolism, DNA incorporation with lack of repair, and lactate production for 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)-5-iodouracil in U-937 and MOLT-4 cells

1 reference

12 December 2020

The internal equilibrium of the hammerhead ribozyme reaction

1 reference

12 December 2020

Neomycin inhibition of the hammerhead ribozyme involves ionic interactions

1 reference

12 December 2020

Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance

1 reference

12 December 2020

Chemically modified hammerhead ribozymes with improved catalytic rates

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12 December 2020

A unique mechanism for RNA catalysis: the role of metal cofactors in hairpin ribozyme cleavage

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12 December 2020

RNA-catalysed carbon–carbon bond formation

1 reference

12 December 2020

Pharmacokinetics of an antiangiogenic ribozyme (ANGIOZYME) in the mouse

1 reference

12 December 2020

High cleavage activity and stability of hammerhead ribozymes with a uniform 2'-amino pyrimidine modification

1 reference

12 December 2020

10.1017/S1355838202014723

Identifiers

DOI

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6 July 2017

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6 July 2017

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