Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. (Q30499793)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21464312%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

title

Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination (English)

1 reference

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27 January 2020

main subject

protein ubiquitination

1 reference

1 reference

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27 January 2020

Hakryul Jo

1 reference

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27 January 2020

Pang-Kuo Lo

1 reference

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27 January 2020

Yitang Li

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27 January 2020

Sarah Green

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27 January 2020

Jake Wang

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27 January 2020

Leslie E Silberstein

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27 January 2020

Keqiang Ye

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27 January 2020

Hexin Chen

1 reference

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27 January 2020

Hongbo R Luo

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27 January 2020

language of work or name

English

0 references

publication date

4 April 2011

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Proceedings of the National Academy of Sciences of the United States of America

27 January 2020

published in

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27 January 2020

volume

108

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issue

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page(s)

6486-6491

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Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs

27 January 2020

cites work

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Akt isoforms differentially regulate neutrophil functions

20 June 2018

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A comprehensive structure-activity analysis of protein kinase B-alpha (Akt1) inhibitors.

20 June 2018

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The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt

20 June 2018

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The E3 ligase TRAF6 regulates Akt ubiquitination and activation

20 June 2018

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20 June 2018

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PIKKing on PKB: regulation of PKB activity by phosphorylation

20 June 2018

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Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

20 June 2018

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Drug discovery approaches targeting the PI3K/Akt pathway in cancer

20 June 2018

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Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha

20 June 2018

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Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

20 June 2018

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The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

20 June 2018

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Cancer cell-derived clusterin modulates the phosphatidylinositol 3'-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivation

20 June 2018

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Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophils

20 June 2018

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Defining the role of mTOR in cancer

20 June 2018

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A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

20 June 2018

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AKT/PKB signaling: navigating downstream

20 June 2018

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

20 June 2018

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The centrosome in human genetic disease

20 June 2018

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Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

20 June 2018

1 reference

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Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.

20 June 2018

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Akt as a mediator of cell death

20 June 2018

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Association of insulin receptor substrate 1 with simian virus 40 large T antigen

20 June 2018

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Chemically targeting the PI3K family

20 June 2018

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Targeting the gatekeeper residue in phosphoinositide 3-kinases

21 January 2018

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Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions

21 January 2018

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TTC3 ubiquitination terminates Akt-ivation

21 January 2018

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Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors

21 January 2018

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A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1073/PNAS.1019062108

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21464312%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

0 references

1 reference

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27 January 2020

PubMed publication ID

21464312

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21464312%20AND%20SRC:MED&resulttype=core&format=json