TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I. (Q29871423)

9 May 2017

title

TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I. (English)

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Transmembrane protein 129, E3 ubiquitin ligase

9 May 2017

main subject

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ubiquitin protein ligase activity

GOA release 2020-03-11

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GOA release 2020-03-11

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James A Nathan

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Helen R Stagg

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Dick J H van den Boomen

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9 May 2017

Richard T Timms

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9 May 2017

Guinevere L Grice

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9 May 2017

Karsten Skødt

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9 May 2017

Paul J Lehner

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9 May 2017

language of work or name

English

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publication date

16 July 2014

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Proceedings of the National Academy of Sciences of the United States of America

9 May 2017

published in

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9 May 2017

volume

111

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9 May 2017

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9 May 2017

page(s)

11425-11430

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The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology

9 May 2017

cites work

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https://api.crossref.org/works/10.1073%2FPNAS.1409099111

RING domain E3 ubiquitin ligases

10 May 2017

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1409099111

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER

10 May 2017

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1409099111

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

10 May 2017

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1409099111

A membrane protein required for dislocation of misfolded proteins from the ER

10 May 2017

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1409099111

Haploid genetic screens in human cells identify host factors used by pathogens

10 May 2017

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1409099111

A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised

10 May 2017

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1409099111

HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation

10 May 2017

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1409099111

Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane

10 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128144

Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases

12 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128144

The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol

12 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128144

Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms

12 May 2017

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The mammalian endoplasmic reticulum-associated degradation system

3 June 2018

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New paradigms for HIV/AIDS vaccine development

3 June 2018

1 reference

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Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum

3 June 2018

1 reference

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Quality and quantity control at the endoplasmic reticulum

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128144

Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates

3 June 2018

1 reference

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Ubiquitination, ubiquitin-like modifiers, and deubiquitination in viral infection

3 June 2018

1 reference

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Viral avoidance and exploitation of the ubiquitin system.

3 June 2018

1 reference

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SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128144

Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128144

Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions

3 June 2018

1 reference

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SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128144

Ubiquitination of MHC class I heavy chains is essential for dislocation by human cytomegalovirus-encoded US2 but not US11.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128144

Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond

3 June 2018

1 reference

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Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128144

Amino acid composition of alpha1/alpha2 domains and cytoplasmic tail of MHC class I molecules determine their susceptibility to human cytomegalovirus US11-mediated down-regulation.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128144

Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128144

Membrane-specific, host-derived factors are required for US2- and US11-mediated degradation of major histocompatibility complex class I molecules

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128144

Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4128144

3 June 2018

Identifiers

DOI

10.1073/PNAS.1409099111

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ADS bibcode

2014PNAS..11111425V

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1 reference

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