HSP90 and the chaperoning of cancer (Q29617504)

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16175177

30 April 2017

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Whitesell L

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16175177

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16175177

30 April 2017

Lindquist SL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16175177

30 April 2017

language of work or name

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30 April 2017

publication date

October 2005

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16175177

30 April 2017

published in

Nature Reviews Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16175177

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16175177

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16175177

30 April 2017

page(s)

761-72

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16175177

Hsp70 and Hsp90--a relay team for protein folding

30 April 2017

cites work

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Heat-shock proteins as regulators of apoptosis

31 March 2020

1 reference

Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection

31 March 2020

1 reference

Heat shock response--pathophysiological implications

31 March 2020

1 reference

Role of the heat shock response and molecular chaperones in oncogenesis and cell death

31 March 2020

1 reference

Hsp90 & Co. - a holding for folding

31 March 2020

1 reference

The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review

31 March 2020

1 reference

Reduced levels of hsp90 compromise steroid receptor action in vivo

31 March 2020

1 reference

Disassembly of transcriptional regulatory complexes by molecular chaperones

31 March 2020

1 reference

Tumor-derived, chaperone-rich cell lysate activates dendritic cells and elicits potent antitumor immunity

31 March 2020

1 reference

Heat shock proteins and their use as anticancer vaccines.

31 March 2020

1 reference

Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent

31 March 2020

1 reference

In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone

31 March 2020

1 reference

The hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors

31 March 2020

1 reference

Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone

31 March 2020

1 reference

Dynamic remodeling of transcription complexes by molecular chaperones

31 March 2020

1 reference

Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution.

31 March 2020

1 reference

Hsp90 as a capacitor for morphological evolution

31 March 2020

1 reference

Hsp90 as a capacitor of phenotypic variation

31 March 2020

1 reference

Waddington's widget: Hsp90 and the inheritance of acquired characters.

31 March 2020

1 reference

Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance

31 March 2020

1 reference

Between genotype and phenotype: protein chaperones and evolvability

31 March 2020

1 reference

Anomalous expression of the HLA-DR alpha and beta chains in ovarian and other cancers

31 March 2020

1 reference

Correlation of the survival of ovarian cancer patients with mRNA expression of the 60-kD heat-shock protein HSP-60.

31 March 2020

1 reference

Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications

31 March 2020

1 reference

Differential expression of 70-kDa heat shock-protein in human oral tumorigenesis

31 March 2020

1 reference

Expression of heat shock protein 72 in renal cell carcinoma: possible role and prognostic implications in cancer patients

31 March 2020

1 reference

Analysis of heat-shock protein expression in myeloid leukaemia cells by flow cytometry

31 March 2020

1 reference

High constitutive expression of heat shock protein 90α in human acute leukemia cells

31 March 2020

1 reference

Clinical and biological significance of HSP89 alpha in human breast cancer

31 March 2020

1 reference

Expression and roles of heat shock proteins in human breast cancer.

31 March 2020

1 reference

Prognostic significance of heat shock proteins HSP70 and HSP90 in endometrial carcinomas

31 March 2020

1 reference

Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy

31 March 2020

1 reference

Molecular chaperones and the stress of oncogenesis

31 March 2020

1 reference

Escaping cell death: survival proteins in cancer

31 March 2020

1 reference

Drug resistance against gemcitabine and topotecan mediated by constitutive hsp70 overexpression in vitro: implication of quercetin as sensitiser in chemotherapy

31 March 2020

1 reference

The chaperone function of hsp70 is required for protection against stress-induced apoptosis

31 March 2020

1 reference

Hsp72 inhibits apoptosis upstream of the mitochondria and not through interactions with Apaf-1.

31 March 2020

1 reference

Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis

31 March 2020

1 reference

Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.

31 March 2020

1 reference

Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms

31 March 2020

1 reference

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

31 March 2020

1 reference

Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis

31 March 2020

1 reference

TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90

31 March 2020

1 reference

Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90.

31 March 2020

1 reference

A cellular protein that associates with the transforming protein of Rous sarcoma virus is also a heat-shock protein

31 March 2020

1 reference

Interaction Between the Rous Sarcoma Virus Transforming Protein and Two Cellular Phosphoproteins: Analysis of the Turnover and Distribution of This Complex

31 March 2020

1 reference

Heat-shock protein hsp90 governs the activity of pp60v-src kinase

31 March 2020

1 reference

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

31 March 2020

1 reference

Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures

31 March 2020

1 reference

Hsp90 chaperones wild-type p53 tumor suppressor protein

31 March 2020

1 reference

The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent

31 March 2020

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Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

31 March 2020

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Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell

31 March 2020

1 reference

Hsp90 isoforms: functions, expression and clinical importance

31 March 2020

1 reference

Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness

31 March 2020

1 reference

The role of Hsp90N, a new member of the Hsp90 family, in signal transduction and neoplastic transformation

31 March 2020

1 reference

Structure, function, and mechanism of the Hsp90 molecular chaperone

31 March 2020

1 reference

Structure and functional relationships of Hsp90.

31 March 2020

1 reference

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

31 March 2020

1 reference

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

31 March 2020

1 reference

Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions

31 March 2020

1 reference

Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding

31 March 2020

1 reference

The crystal structure of the carboxy-terminal dimerization domain of htpG, the Escherichia coli Hsp90, reveals a potential substrate binding site

31 March 2020

1 reference

GHKL, an emergent ATPase/kinase superfamily

31 March 2020

1 reference

Independent ATPase activity of Hsp90 subunits creates a flexible assembly platform

31 March 2020

1 reference

The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)

31 March 2020

1 reference

Hsp90 and Cdc37 -- a chaperone cancer conspiracy.

31 March 2020

1 reference

A Nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90. N-terminal nucleotide binding unmasks a C-terminal binding pocket

31 March 2020

1 reference

Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery

31 March 2020

1 reference

Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1

31 March 2020

1 reference

Binding of ATP to heat shock protein 90: evidence for an ATP-binding site in the C-terminal domain

31 March 2020

1 reference

Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine

31 March 2020

1 reference

Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

31 March 2020

1 reference

Quantum chemical calculations and mutational analysis suggest heat shock protein 90 catalyzes trans-cis isomerization of geldanamycin

31 March 2020

1 reference

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

31 March 2020

1 reference

Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

31 March 2020

1 reference

Mutational analysis of Hsp90 function: interactions with a steroid receptor and a protein kinase

31 March 2020

1 reference

Development of a fluorescence polarization assay for the molecular chaperone Hsp90.

31 March 2020

1 reference

Therapeutic and diagnostic implications of Hsp90 activation

31 March 2020

1 reference

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

31 March 2020

1 reference

Altered states: selectively drugging the Hsp90 cancer chaperone

31 March 2020

1 reference

Novobiocin induces a distinct conformation of Hsp90 and alters Hsp90-cochaperone-client interactions

31 March 2020

1 reference

Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins

31 March 2020

1 reference

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

31 March 2020

1 reference

The heat shock protein 90-targeting drug cisplatin selectively inhibits steroid receptor activation

31 March 2020

1 reference

Cell-cycle arrest and p53 accumulation induced by geldanamycin in human ovarian tumour cells

31 March 2020

1 reference

Geldanamycin induces mitotic catastrophe and subsequent apoptosis in human glioma cells

31 March 2020

1 reference

Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin

31 March 2020

1 reference

Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.

31 March 2020

1 reference

Genes and Proteins Governing the Cellular Sensitivity to HSP90 Inhibitors: A Mechanistic Perspective

31 March 2020

1 reference

BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90.

31 March 2020

1 reference

Ubiquitination and proteasomal degradation of nucleophosmin-anaplastic lymphoma kinase induced by 17-allylamino-demethoxygeldanamycin: role of the co-chaperone carboxyl heat shock protein 70-interacting protein

31 March 2020

1 reference

Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone.

31 March 2020

1 reference

17-(Allylamino)-17-demethoxygeldanamycin activity in human melanoma models

31 March 2020

1 reference

Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia

31 March 2020

1 reference

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

31 March 2020

1 reference

Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila.

31 March 2020

1 reference

Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1.

31 March 2020

1 reference

DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

31 March 2020

1 reference

Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer

31 March 2020

1 reference

Proteasome inhibition as a novel therapeutic target in human cancer.

31 March 2020

1 reference

Phase I and pharmacologic study of 17-(allylamino)-17-demethoxygeldanamycin in adult patients with solid tumors.

31 March 2020

1 reference

Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies

31 March 2020

1 reference

Use of methotrexate-based peptide substrates to characterize the substrate specificity of prostate-specific membrane antigen (PSMA).

31 March 2020

1 reference

Novel biologically based therapies for Waldenstrom's macroglobulinemia

31 March 2020

1 reference

Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228

31 March 2020

1 reference

Adenine derived inhibitors of the molecular chaperone HSP90-SAR explained through multiple X-ray structures

31 March 2020

1 reference

Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase

31 March 2020

1 reference

High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity

31 March 2020

1 reference

The anticancer activity of the fungal metabolite terrecyclic acid A is associated with modulation of multiple cellular stress response pathways

31 March 2020

1 reference

Synthesis and evaluation of geldanamycin-testosterone hybrids

31 March 2020

1 reference

Engineered biosynthesis of geldanamycin analogs for Hsp90 inhibition.

31 March 2020

1 reference

Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts

31 March 2020

1 reference

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

31 March 2020

1 reference

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

31 March 2020

1 reference

Functional requirement of p23 and Hsp90 in telomerase complexes

31 March 2020

1 reference

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

31 March 2020

1 reference

Oncogenic mutations reduce the stability of SRC kinase.

31 March 2020

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16175177

31 March 2020

Identifiers

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1009936643

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1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16175177

PubMed publication ID

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017