Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes (Q28650442)

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20 February 2020

title

Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes (English)

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20 February 2020

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20 February 2020

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20 February 2020

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20 February 2020

Iannis Aifantis

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20 February 2020

author name string

Barbara Fontanals-Cirera

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20 February 2020

Vivien Low

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20 February 2020

Panagiotis Ntziachristos

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20 February 2020

Stephanie K Yuen

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20 February 2020

Claudia D Lovell

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20 February 2020

Yoshiya Yonekubo

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20 February 2020

Guangtao Zhang

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20 February 2020

Elena Rusinova

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20 February 2020

Guillermo Gerona-Navarro

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20 February 2020

Marta Cañamero

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20 February 2020

Michael Ohlmeyer

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20 February 2020

Ming-Ming Zhou

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20 February 2020

language of work or name

English

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publication date

26 September 2014

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20 February 2020

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volume

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issue

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page(s)

234-247

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Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains

20 February 2020

cites work

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Super-enhancers in the control of cell identity and disease

17 March 2017

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The Mediator complex and transcription regulation

17 March 2017

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BET domain co-regulators in obesity, inflammation and cancer

17 March 2017

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Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition

17 March 2017

1 reference

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BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain

17 March 2017

1 reference

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Histone recognition and large-scale structural analysis of the human bromodomain family

17 March 2017

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Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation

17 March 2017

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

17 March 2017

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

17 March 2017

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A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes

17 March 2017

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Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosa

17 March 2017

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Suppression of inflammation by a synthetic histone mimic

17 March 2017

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Selective inhibition of BET bromodomains

17 March 2017

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Cooperative binding of two acetylation marks on a histone tail by a single bromodomain

17 March 2017

1 reference

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The role of human bromodomains in chromatin biology and gene transcription

17 March 2017

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A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity

17 March 2017

1 reference

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The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription

17 March 2017

1 reference

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Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription

17 March 2017

1 reference

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Regulation of P-TEFb elongation complex activity by CDK9 acetylation

17 March 2017

1 reference

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Dissecting self-renewal in stem cells with RNA interference

17 March 2017

1 reference

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The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells

17 March 2017

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Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4.

17 March 2017

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The CBP co-activator is a histone acetyltransferase

17 March 2017

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The transcriptional coactivators p300 and CBP are histone acetyltransferases

17 March 2017

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The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins

17 March 2017

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brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2

17 March 2017

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Selective inhibition of tumor oncogenes by disruption of super-enhancers

17 March 2017

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Master transcription factors and mediator establish super-enhancers at key cell identity genes

7 April 2017

1 reference

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

7 April 2017

1 reference

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BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy

7 April 2017

1 reference

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BET bromodomains mediate transcriptional pause release in heart failure

3 June 2018

1 reference

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The histone acetyltransferase MOF is a key regulator of the embryonic stem cell core transcriptional network

3 June 2018

1 reference

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Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells

3 June 2018

1 reference

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Chromatin-modifying enzymes as modulators of reprogramming

3 June 2018

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Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

3 June 2018

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Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells

3 June 2018

1 reference

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Pluripotency factors in embryonic stem cells regulate differentiation into germ layers

3 June 2018

1 reference

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Sequence-specific regulator Prdm14 safeguards mouse ESCs from entering extraembryonic endoderm fates

3 June 2018

1 reference

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Sox2 is essential for formation of trophectoderm in the preimplantation embryo

3 June 2018

1 reference

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Smarcc1/Baf155 couples self-renewal gene repression with changes in chromatin structure in mouse embryonic stem cells

3 June 2018

1 reference

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Regulation of aurora B expression by the bromodomain protein Brd4.

3 June 2018

1 reference

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Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation

3 June 2018

1 reference

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Double bromodomain-containing gene Brd2 is essential for embryonic development in mouse

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317728

An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317728

Chromatin in pluripotent embryonic stem cells and differentiation

3 June 2018

1 reference

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Oct-4: gatekeeper in the beginnings of mammalian development.

3 June 2018

1 reference

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Identification and characterization of BRDT: A testis-specific gene related to the bromodomain genes RING3 and Drosophila fsh.

3 June 2018

1 reference

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10.1016/J.CELREP.2014.08.055

3 June 2018

Identifiers

DOI

2 references

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20 February 2020

1 reference

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20 February 2020

PubMed publication ID

25263550

2 references

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