Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis (Q28594871)

1 February 2017

title

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis (English)

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1 February 2017

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GOA release 2020-03-11

X. Xia

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1 February 2017

S. Qian

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1 February 2017

S. Soriano

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1 February 2017

Y. Wu

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1 February 2017

A. M. Fletcher

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1 February 2017

X. J. Wang

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1 February 2017

E. H. Koo

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1 February 2017

X. Wu

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1 February 2017

H. Zheng

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1 February 2017

language of work or name

English

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publication date

11 September 2001

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Proceedings of the National Academy of Sciences of the United States of America

1 February 2017

published in

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1 February 2017

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1 February 2017

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1 February 2017

page(s)

10863–10868

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Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila

1 February 2017

cites work

1 reference

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17 March 2017

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

17 March 2017

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Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway

17 March 2017

1 reference

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An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Presenilin is required for activity and nuclear access of Notch in Drosophila

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

17 March 2017

1 reference

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Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

17 March 2017

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A common human skin tumour is caused by activating mutations in beta-catenin

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Direct association of presenilin-1 with beta-catenin

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Identification of c-MYC as a target of the APC pathway

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Skeletal and CNS defects in Presenilin-1-deficient mice

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Functional interaction of beta-catenin with the transcription factor LEF-1

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Cyclin D1 is a nuclear protein required for cell cycle progression in G1

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

A screen for mutations that suppress the phenotype of Drosophila armadillo, the beta-catenin homolog.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Keratoacanthoma: a clinically distinct variant of well differentiated squamous cell carcinoma.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Presenilin affects arm/beta-catenin localization and function in Drosophila.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Beta-catenin: a key mediator of Wnt signaling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Interaction between Wingless and Notch signaling pathways mediated by dishevelled.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Overexpression of cyclin D1 in mouse skin carcinogenesis

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=58565

Regulation of Thy-1 gene expression in transgenic mice

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/11517342

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Early overexpression of cyclin D1 protein in mouse skin carcinogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11517342

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cyclin D1 overexpression in mouse epidermis increases cyclin-dependent kinase activity and cell proliferation in vivo but does not affect skin tumor development

1 reference

https://pubmed.ncbi.nlm.nih.gov/11517342

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.191284198

1 reference

ADS bibcode

2001PNAS...9810863X

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1 reference

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