Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model (Q28590872)

31 January 2017

title

Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model (English)

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FMS-like tyrosine kinase 3

31 January 2017

main subject

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GOA release 2020-03-11

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Kogo Takamiya

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31 January 2017

Li Li

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31 January 2017

Obdulio Piloto

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31 January 2017

Ho Bao Nguyen

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31 January 2017

Frederick Racke

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31 January 2017

David Huso

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31 January 2017

Donald Small

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31 January 2017

language of work or name

English

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publication date

1 April 2008

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31 January 2017

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31 January 2017

volume

111

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31 January 2017

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31 January 2017

page(s)

3849–3858

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Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

31 January 2017

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Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder

17 March 2017

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17 March 2017

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17 March 2017

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17 March 2017

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17 March 2017

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17 March 2017

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Substrate specificities and identification of a putative binding site for PI3K in the carboxy tail of the murine Flt3 receptor tyrosine kinase

17 March 2017

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Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

17 March 2017

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STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells

17 March 2017

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FLT3 internal tandem duplication in CD34+/CD33- precursors predicts poor outcome in acute myeloid leukemia

17 March 2017

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The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice

29 September 2017

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Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival

29 September 2017

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29 September 2017

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Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

29 September 2017

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Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

29 September 2017

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A direct measurement of the radiation sensitivity of normal mouse bone marrow cells

29 September 2017

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FLT3: ITDoes matter in leukemia

29 September 2017

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29 September 2017

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29 September 2017

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PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model

29 September 2017

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FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

29 September 2017

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Inhibition of FLT3-mediated transformation by use of a tyrosine kinase inhibitor

29 September 2017

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Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells

29 September 2017

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Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells

29 September 2017

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29 September 2017

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Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified

29 September 2017

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Mitogenic Signalling and Substrate Specificity of the Flk2/Flt3 Receptor Tyrosine Kinase in Fibroblasts and Interleukin 3-Dependent Hematopoietic Cells

29 September 2017

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29 September 2017

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Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis

29 September 2017

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Constitutive Fms-like tyrosine kinase 3 activation results in specific changes in gene expression in myeloid leukaemic cells

3 June 2018

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Transgenic mice expressing Tel-FLT3, a constitutively activated form of FLT3, develop myeloproliferative disease.

27 November 2018

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FLT3 internal tandem duplication mutations induce myeloproliferative or lymphoid disease in a transgenic mouse model.

27 November 2018

1 reference

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Inhibitory anti-FLT3 antibodies are capable of mediating antibody-dependent cell-mediated cytotoxicity and reducing engraftment of acute myelogenous leukemia blasts in nonobese diabetic/severe combined immunodeficient mice

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275036

FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275036

Effects of SU5416, a small molecule tyrosine kinase receptor inhibitor, on FLT3 expression and phosphorylation in patients with refractory acute myeloid leukemia

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275036

Prognostically useful gene-expression profiles in acute myeloid leukemia.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275036

Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275036

Assessing permanent damage to primitive hematopoietic stem cells after chemotherapy using the competitive repopulation assay

27 November 2018

1 reference

12 December 2020

The FLT3 ligand is a direct and potent stimulator of the growth of primitive and committed human CD34+ bone marrow progenitor cells in vitro

1 reference

12 December 2020

Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia

1 reference

12 December 2020

Transient nature of early haematopoietic spleen colonies

1 reference

12 December 2020

Internal tandem duplication of the flt3 gene found in acute myeloid leukemia

1 reference

12 December 2020

Multi-level effects of flt3 ligand on human hematopoiesis: expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors

1 reference

12 December 2020

Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product

1 reference

12 December 2020

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

1 reference

12 December 2020

10.1182/BLOOD-2007-08-109942

Identifiers

DOI

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31 January 2017

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1 reference