Ectonucleotide pyrophosphatase/phosphodiesterase 1 (Q28556695)

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mammalian protein found in Rattus norvegicus

E-NPP 1
plasma-cell membrane glycoprotein PC-1
ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Enpp1
phosphodiesterase I/nucleotide pyrophosphatase 1

Language	Label	Description	Also known as
English	Ectonucleotide pyrophosphatase/phosphodiesterase 1	mammalian protein found in Rattus norvegicus	E-NPP 1 plasma-cell membrane glycoprotein PC-1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Enpp1 phosphodiesterase I/nucleotide pyrophosphatase 1

Statements

1 reference

25 May 2022

UniProt protein ID

Somatomedin B-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q924C3

Alkaline-phosphatase-like, core domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q924C3

Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q924C3

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Somatomedin B, chordata, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

based on heuristic

inferred from protein domain or family

Extracellular Endonuclease, subunit A, protein family

1 reference

based on heuristic

inferred from protein domain or family

DNA/RNA non-specific endonuclease family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

nucleic acid binding

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

catalytic activity

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

phosphodiesterase I activity

determination method or standard

nucleotide diphosphatase activity

determination method or standard

scavenger receptor activity

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

calcium ion binding

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

zinc ion binding

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

polysaccharide binding

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

NADH pyrophosphatase activity

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

phosphodiesterase I activity

determination method or standard

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

9 May 2019

Biochemical analysis of ecto-nucleotide pyrophosphatase phosphodiesterase activity in brain membranes indicates involvement of NPP1 isoenzyme in extracellular hydrolysis of diadenosine polyphosphates in central nervous system

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

nucleotide diphosphatase activity

determination method or standard

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

protein homodimerization activity

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

nucleoside-triphosphate diphosphatase activity

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

cyclic-GMP-AMP hydrolase activity

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

extracellular region

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

plasma membrane

determination method or standard

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

9 May 2019

Biochemical analysis of ecto-nucleotide pyrophosphatase phosphodiesterase activity in brain membranes indicates involvement of NPP1 isoenzyme in extracellular hydrolysis of diadenosine polyphosphates in central nervous system

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

9 May 2019

UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

integral component of plasma membrane

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

basolateral plasma membrane

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

determination method or standard

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

cell projection

determination method or standard

1 reference

9 May 2019

Expression of membrane-bound NPP-type ecto-phosphodiesterases in rat podocytes cultured at normal and high glucose concentrations

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

neuron projection

determination method or standard

1 reference

9 May 2019

Immunolocalization of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) in the rat forebrain

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

neuronal cell body

determination method or standard

1 reference

9 May 2019

Immunolocalization of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) in the rat forebrain

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

determination method or standard

1 reference

9 May 2019

Expression of membrane-bound NPP-type ecto-phosphodiesterases in rat podocytes cultured at normal and high glucose concentrations

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

determination method or standard

1 reference

9 May 2019

Biochemical analysis of ecto-nucleotide pyrophosphatase phosphodiesterase activity in brain membranes indicates involvement of NPP1 isoenzyme in extracellular hydrolysis of diadenosine polyphosphates in central nervous system

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

apical dendrite

determination method or standard

1 reference

9 May 2019

Immunolocalization of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) in the rat forebrain

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

determination method or standard

1 reference

9 May 2019

Immunolocalization of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) in the rat forebrain

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

biological process

receptor-mediated endocytosis

determination method or standard

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

immune response

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

determination method or standard

1 reference

30 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q924C3

determination method or standard

biomineral tissue development

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

nucleic acid phosphodiester bond hydrolysis

determination method or standard

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

ATP metabolic process

determination method or standard

1 reference

30 May 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q924C3

determination method or standard

liver development

determination method or standard

1 reference

9 May 2019

Differential regulation of the expression of nucleotide pyrophosphatases/phosphodiesterases in rat liver

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

nucleoside triphosphate catabolic process

determination method or standard

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

response to mechanical stimulus

determination method or standard

1 reference

9 May 2019

Unilateral anterior crossbite induces aberrant mineral deposition in degenerative temporomandibular cartilage in rats

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

cerebellum development

determination method or standard

1 reference

9 May 2019

Expression mapping of ectonucleotide pyrophosphatase/phosphodiesterase 1-3 (E-NPP1-3) in different brain structures during rat development

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

striatum development

determination method or standard

1 reference

9 May 2019

Expression mapping of ectonucleotide pyrophosphatase/phosphodiesterase 1-3 (E-NPP1-3) in different brain structures during rat development

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

hippocampus development

determination method or standard

1 reference

9 May 2019

Expression mapping of ectonucleotide pyrophosphatase/phosphodiesterase 1-3 (E-NPP1-3) in different brain structures during rat development

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

olfactory bulb development

determination method or standard

1 reference

9 May 2019

Expression mapping of ectonucleotide pyrophosphatase/phosphodiesterase 1-3 (E-NPP1-3) in different brain structures during rat development

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

cerebral cortex development

determination method or standard

1 reference

9 May 2019

Expression mapping of ectonucleotide pyrophosphatase/phosphodiesterase 1-3 (E-NPP1-3) in different brain structures during rat development

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

regulation of bone mineralization

determination method or standard

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

inorganic diphosphate transport

determination method or standard

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

negative regulation of fat cell differentiation

determination method or standard

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

cellular response to mechanical stimulus

determination method or standard

1 reference

9 May 2019

Expression of ectonucleotide pyrophosphatase-1 in end-plate chondrocytes with transforming growth factor beta 1 siRNA interference by cyclic mechanical tension

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

cellular response to cAMP

determination method or standard

1 reference

9 May 2019

Cyclic AMP-dependent down regulation of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) in rat C6 glioma

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

cellular response to acidic pH

determination method or standard

1 reference

9 May 2019

Acidosis is a key regulator of osteoblast ecto-nucleotidase pyrophosphatase/phosphodiesterase 1 (NPP1) expression and activity

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

cellular response to transforming growth factor beta stimulus

determination method or standard

1 reference

9 May 2019

Expression of ectonucleotide pyrophosphatase-1 in end-plate chondrocytes with transforming growth factor beta 1 siRNA interference by cyclic mechanical tension

Rat genome database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

vesicle-mediated transport

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

melanocyte differentiation

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

negative regulation of bone mineralization

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

negative regulation of hh target transcription factor activity

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

determination method or standard

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924C3

determination method or standard

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSRNOP00000019519

1 reference

ensembl Release 106

Ensembl protein ID

ENSRNOP00000019519

Sitelinks

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Multilingual sites(0 entries)

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