Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics (Q28539047)

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Paula Faral-Tello

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PLoS Neglected Tropical Diseases

4 June 2020

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English

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May 2014

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e2844

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Creative Commons Attribution 4.0 International

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start time

22 May 2014

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April 2022 Public Data File from Crossref

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cites work

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Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formation

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Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites.

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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3 June 2018

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3 June 2018

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Biological aspects of the Dm 28c clone of Trypanosoma cruzi after metacyclogenesis in chemically defined media

3 June 2018

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Interaction of benznidazole reactive metabolites with nuclear and kinetoplastic DNA, proteins and lipids from Trypanosoma cruzi

3 June 2018

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3 June 2018

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21 January 2018

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21 January 2018

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Multiple NADPH-cytochrome P450 reductases from Trypanosoma cruzi suggested role on drug resistance.

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Deletion of copies of the gene encoding old yellow enzyme (TcOYE), a NAD(P)H flavin oxidoreductase, associates with in vitro-induced benznidazole resistance in Trypanosoma cruzi.

21 January 2018

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21 January 2018

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Chemical Informatics Functionality in R

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21 January 2018

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27 November 2018

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27 November 2018

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21 January 2018

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12 December 2020

Effects of nitroheterocyclic drugs on macromolecule synthesis and degradation in Trypanosoma cruzi

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Damage of Trypanosoma cruzi deoxyribonucleic acid by nitroheterocyclic drugs

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Nitroimidazole bioreductive metabolism. Quantitation and characterisation of mouse tissue benznidazole nitroreductases in vivo and in vitro

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Importance of thiols in the reductive binding of 2-nitroimidazoles to macromolecules

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Effects of nifurtimox and benznidazole upon glutathione and trypanothione content in epimastigote, trypomastigote and amastigote forms of Trypanosoma cruzi

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12 December 2020

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10.1371/JOURNAL.PNTD.0002844

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DOI

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4 June 2020

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4 June 2020

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24853684

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