Domain antibodies: proteins for therapy (Q28211838)

https://api.crossref.org/works/10.1016/J.TIBTECH.2003.08.007

24 March 2024

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https://api.crossref.org/works/10.1016/J.TIBTECH.2003.08.007

24 March 2024

author name string

Chris Herring

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Lucy J. Holt

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14573361

24 March 2024

Laurent S. Jespers

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14573361

24 March 2024

Benjamin P. Woolven

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24 March 2024

Ian M. Tomlinson

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14573361

full work available at URL

24 March 2024

language of work or name

English

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publication date

November 2003

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https://api.elsevier.com/content/article/PII:S0167779903002452?httpAccept=text/xml

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Crossref

DOI

https://api.crossref.org/works/10.1016/J.TIBTECH.2003.08.007

https://api.elsevier.com/content/article/PII:S0167779903002452?httpAccept=text/plain

24 March 2024

1 reference

Crossref

DOI

https://api.crossref.org/works/10.1016/J.TIBTECH.2003.08.007

Continuous cultures of fused cells secreting antibody of predefined specificity

24 March 2024

published in

Trends in Biotechnology

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volume

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issue

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page(s)

484-90

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cites work

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https://api.crossref.org/works/10.1016/J.TIBTECH.2003.08.007

Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli

24 March 2024

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Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein

24 March 2024

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Amino acid sequence studies with Bence-Jones proteins

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Selection and identification of single domain antibody fragments from camel heavy-chain antibodies

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Potent enzyme inhibitors derived from dromedary heavy-chain antibodies

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Structural analysis of the nurse shark (new) antigen receptor (NAR): molecular convergence of NAR and unusual mammalian immunoglobulins

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An antibody single-domain phage display library of a native heavy chain variable region: isolation of functional single-domain VH molecules with a unique interface.

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Antibody VH domains as small recognition units

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Building novel binding ligands to B7.1 and B7.2 based on human antibody single variable light chain domains

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Isolation of high affinity human antibodies directly from large synthetic repertoires.

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Cardiolipin binding a light chain from lupus-prone mice

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The crystal structure of a llama heavy chain variable domain

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A single-domain antibody fragment in complex with RNase A: non-canonical loop structures and nanomolar affinity using two CDR loops

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'Camelising' human antibody fragments: NMR studies on VH domains.

24 March 2024

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Solution structure and backbone dynamics of an antigen-free heavy chain variable domain (VHH) from Llama

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Solution structure of a llama single-domain antibody with hydrophobic residues typical of the VH/VL interface

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Canonical antigen-binding loop structures in immunoglobulins: more structures, more canonical classes?

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Sequence and structure of VH domain from naturally occurring camel heavy chain immunoglobulins lacking light chains

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Camelid heavy-chain variable domains provide efficient combining sites to haptens

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Crystal structure of a camel single-domain VH antibody fragment in complex with lysozyme

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Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology

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Camel heavy-chain antibodies: diverse germline V(H)H and specific mechanisms enlarge the antigen-binding repertoire

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Affinity selection of a camelized V(H) domain antibody inhibitor of hepatitis C virus NS3 protease

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Solution properties of Escherichia coli-expressed VH domain of anti-neuraminidase antibody NC41

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Molecular dynamics simulations highlight mobile regions in proteins: A novel suggestion for converting a murine V(H) domain into a more tractable species

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Affinity improvement of single antibody VH domains: residues in all three hypervariable regions affect antigen binding

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Rearrangement of the former VL interface in the solution structure of a camelised, single antibody VH domain

24 March 2024

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Selection by phage display of llama conventional V(H) fragments with heavy chain antibody V(H)H properties

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Length distribution of CDRH3 in antibodies

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Optimal design features of camelized human single-domain antibody libraries

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Biophysical properties of human antibody variable domains

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Biophysical Properties of Camelid VHHDomains Compared to Those of Human VH3 Domains†

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Comparison of physical chemical properties of llama VHH antibody fragments and mouse monoclonal antibodies

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Single-domain antibody fragments with high conformational stability

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Thermal Unfolding of a Llama Antibody Fragment: A Two-State Reversible Process†

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Stability engineering of antibody single-chain Fv fragments

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Structure-based improvement of the biophysical properties of immunoglobulin VH domains with a generalizable approach

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The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops

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By-passing immunisation. Human antibodies from synthetic repertoires of germline VH gene segments rearranged in vitro

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Synthetic human antibodies and a strategy for protein engineering

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Exploiting sequence space: shuffling in vivo formed complementarity determining regions into a master framework

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Selection of phage antibodies by binding affinity

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Mimicking somatic hypermutation: affinity maturation of antibodies displayed on bacteriophage using a bacterial mutator strain

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By-passing immunization: building high affinity human antibodies by chain shuffling

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Expression, refolding, and ferritin-binding activity of the isolated VL-domain of monoclonal antibody F11

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Partially structured state of the functional VH domain of the mouse anti-ferritin antibody F11

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Protein refolding for industrial processes

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Large-scale production of VHH antibody fragments by Saccharomyces cerevisiae

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Improved production and function of llama heavy chain antibody fragments by molecular evolution

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Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs

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