HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway (Q28202962)

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16 December 2019

title

HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway (English)

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16 December 2019

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16 December 2019

author name string

Anastassia D Blagoveshchenskaya

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16 December 2019

Laurel Thomas

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16 December 2019

Chien Hui Hung

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16 December 2019

Gary Thomas

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16 December 2019

language of work or name

English

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publication date

1 December 2002

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16 December 2019

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16 December 2019

volume

111

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16 December 2019

issue

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16 December 2019

page(s)

853-866

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The N-Terminus of Nef from HIV-1/SIV Associates with a Protein Complex Containing Lck and a Serine Kinase

16 December 2019

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7 January 2021

A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the beta-phosphate to destabilize GDP on ARF1.

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A Balance of Opposing Signals within the Cytoplasmic Tail Controls the Lysosomal Targeting of P-selectin

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Di-leucine signals mediate targeting of tyrosinase and synaptotagmin to synaptic-like microvesicles within PC12 cells.

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Phosphorylation of class I MHC molecules in the absence of phorbol esters is an intracellular event and may be characteristic of trafficking molecules

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Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS

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Lack of Palmitoylation Redirects p59Hckfrom the Plasma Membrane to p61Hck-positive Lysosomes

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Hck SH3 domain-dependent abrogation of Nef-induced class 1 MHC down-regulation

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The role of ARF and Rab GTPases in membrane transport

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beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis

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The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells

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HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

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Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis

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PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic.

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The plasma membrane as a combat zone in the HIV battlefield

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Strong human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte activity in Sydney Blood Bank Cohort patients infected with nef-defective HIV type 1

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7 January 2021

Live and let die: Nef functions beyond HIV replication

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7 January 2021

Structure--function relationships in HIV-1 Nef.

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7 January 2021

The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes

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7 January 2021

Recycling MHC class I molecules and endosomal peptide loading

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Human adenovirus vectors for gene transfer into mammalian cells

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MHC class I-restricted CTL responses to exogenous antigens

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T cells down-modulate peptide-MHC complexes on APCs in vivo.

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ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1

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Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules

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7 January 2021

Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation.

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7 January 2021

Interaction between Nef and phosphatidylinositol-3-kinase leads to activation of p21-activated kinase and increased production of HIV

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Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking

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Endocytosis in viral replication

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Efficient class I major histocompatibility complex down-regulation by simian immunodeficiency virus Nef is associated with a strong selective advantage in infected rhesus macaques

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Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis

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Paxillin phosphorylation and association with Lck and Pyk2 in anti-CD3- or anti-CD45-stimulated T cells

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Characterization of coated vesicles that participate in endocytic recycling.

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Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes

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7 January 2021

HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

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7 January 2021

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HIV-Nef enhances interleukin-2 production and phosphatidylinositol 3-kinase activity in a human T cell line

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HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway

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Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase

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7 January 2021

PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization

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Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain

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Identifiers

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Consolidated OpenCitations Corpus – April 2017

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16 December 2019

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12526811%20AND%20SRC:MED&resulttype=core&format=json