Spliceosomal UsnRNP biogenesis, structure and function (Q28188106)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11343899%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

review article

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title

Spliceosomal UsnRNP biogenesis, structure and function (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11343899%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

main subject

spliceosome

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language of work or name

English

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publication date

1 June 2001

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Current Opinion in Cell Biology

7 November 2019

published in

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7 November 2019

volume

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7 November 2019

issue

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7 November 2019

page(s)

290-301

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Monomethylated cap structures facilitate RNA export from the nucleus

7 November 2019

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The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

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PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation

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The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis

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SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins.

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Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN).

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The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies

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U snRNP assembly in yeast involves the La protein

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A role for the yeast La protein in U6 snRNP assembly: evidence that the La protein is a molecular chaperone for RNA polymerase III transcripts

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U1 snRNA is cleaved by RNase III and processed through an Sm site-dependent pathway

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Nucleocytoplasmic transport and processing of small nuclear RNA precursors

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Alternative 3'-end processing of U5 snRNA by RNase III.

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Functions of the exosome in rRNA, snoRNA and snRNA synthesis

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Yeast exosome mutants accumulate 3'-extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs

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Three conserved members of the RNase D family have unique and overlapping functions in the processing of 5S, 5.8S, U4, U5, RNase MRP and RNase P RNAs in yeast

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Nucleo-cytoplasmic transport of U snRNPs: definition of a nuclear location signal in the Sm core domain that binds a transport receptor independently of the m3G cap

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7 January 2021

Nuclear import of U snRNPs requires importin beta

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Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure

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Functional characterization of nuclear localization signals in yeast Sm proteins

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7 January 2021

Modifications of U2 snRNA are required for snRNP assembly and pre-mRNA splicing

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7 January 2021

A small nucleolar guide RNA functions both in 2'-O-ribose methylation and pseudouridylation of the U5 spliceosomal RNA

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7 January 2021

Function and synthesis of small nucleolar RNAs

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7 January 2021

Pseudouridine mapping in the Saccharomyces cerevisiae spliceosomal U small nuclear RNAs (snRNAs) reveals that pseudouridine synthase pus1p exhibits a dual substrate specificity for U2 snRNA and tRNA.

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7 January 2021

An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B" spliceosome proteins

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7 January 2021

Modification of U6 spliceosomal RNA is guided by other small RNAs

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7 January 2021

Nucleolar factors direct the 2'-O-ribose methylation and pseudouridylation of U6 spliceosomal RNA

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7 January 2021

Transient nucleolar localization Of U6 small nuclear RNA in Xenopus Laevis oocytes

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7 January 2021

A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro

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7 January 2021

Characterization of U6 snRNA-protein interactions

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7 January 2021

Characterization of Sm-like proteins in yeast and their association with U6 snRNA

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7 January 2021

Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin

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7 January 2021

A Sm-like protein complex that participates in mRNA degradation

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Yeast Sm-like proteins function in mRNA decapping and decay

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Sm and Sm-like proteins belong to a large family: identification of proteins of the U6 as well as the U1, U2, U4 and U5 snRNPs

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7 January 2021

Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs

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7 January 2021

The spliceosomal snRNP core complex of Trypanosoma brucei: cloning and functional analysis reveals seven Sm protein constituents

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7 January 2021

The Sm domain is an ancient RNA-binding motif with oligo(U) specificity

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7 January 2021

Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure

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7 January 2021

Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin

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7 January 2021

Arrangement of RNA and proteins in the spliceosomal U1 small nuclear ribonucleoprotein particle

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7 January 2021

Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin

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7 January 2021

Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5' stem-loop of U4 snRNA

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7 January 2021

Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment

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7 January 2021

A common core RNP structure shared between the small nucleoar box C/D RNPs and the spliceosomal U4 snRNP

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7 January 2021

Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis

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7 January 2021

Identification of both shared and distinct proteins in the major and minor spliceosomes

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7 January 2021

Highly diverged U4 and U6 small nuclear RNAs required for splicing rare AT-AC introns

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7 January 2021

Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals

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7 January 2021

Luc7p, a novel yeast U1 snRNP protein with a role in 5' splice site recognition

1 reference

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7 January 2021

Interaction of the U1 snRNP with nonconserved intronic sequences affects 5' splice site selection.

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7 January 2021

A yeast intronic splicing enhancer and Nam8p are required for Mer1p-activated splicing.

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7 January 2021

The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing

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7 January 2021

Functional association of U2 snRNP with the ATP-independent spliceosomal complex E

1 reference

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7 January 2021

Antibodies specific for N6-methyladenosine react with intact snRNPs U2 and U4/U6

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7 January 2021

Initial recognition of U12-dependent introns requires both U11/5' splice-site and U12/branchpoint interactions

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7 January 2021

Mechanical devices of the spliceosome: motors, clocks, springs, and things

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7 January 2021

Functional recognition of 5' splice site by U4/U6.U5 tri-snRNP defines a novel ATP-dependent step in early spliceosome assembly

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7 January 2021

The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro

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7 January 2021

RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2

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7 January 2021

An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p

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7 January 2021

Active disruption of an RNA-protein interaction by a DExH/D RNA helicase

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7 January 2021

Specific alterations of U1-C protein or U1 small nuclear RNA can eliminate the requirement of Prp28p, an essential DEAD box splicing factor

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7 January 2021

Dynamic exchanges of RNA interactions leading to catalytic core formation in the U12-dependent spliceosome

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7 January 2021

Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome.

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7 January 2021

Metal ion catalysis during splicing of premessenger RNA

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7 January 2021

Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center

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7 January 2021

Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome.

1 reference

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7 January 2021

10.1016/S0955-0674(00)00211-8

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11343899%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11343899%20AND%20SRC:MED&resulttype=core&format=json