The widespread regulation of microRNA biogenesis, function and decay (Q28131796)

Origins and Mechanisms of miRNAs and siRNAs

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Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells

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Regulation of mRNA translation and stability by microRNAs

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Biogenesis of small RNAs in animals

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Origin, biogenesis, and activity of plant microRNAs

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Regulation of MicroRNA Biogenesis: A miRiad of mechanisms

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Transcriptional control of microRNA expression in C. elegans: promoting better understanding

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A MicroRNA feedback circuit in midbrain dopamine neurons

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MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision

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A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands

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Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci

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Posttranscriptional crossregulation between Drosha and DGCR8.

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Post-transcriptional control of DGCR8 expression by the Microprocessor

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The Microprocessor complex mediates the genesis of microRNAs

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Heme is involved in microRNA processing

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TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

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RETRACTED: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function

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Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling

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A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence

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MicroRNAs and cancer epigenetics: a macrorevolution

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Autoinhibition of human dicer by its internal helicase domain

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Dicer and eIF2c are enriched at postsynaptic densities in adult mouse brain and are modified by neuronal activity in a calpain-dependent manner

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Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

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Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease.

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Mammalian microRNAs: experimental evaluation of novel and previously annotated genes

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Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2

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Structural features of microRNA (miRNA) precursors and their relevance to miRNA biogenesis and small interfering RNA/short hairpin RNA design

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Tissue-dependent paired expression of miRNAs

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Many roads to maturity: microRNA biogenesis pathways and their regulation

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Lin28: A microRNA regulator with a macro role

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A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

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LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans

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Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells

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Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA

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TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation

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Zcchc11-dependent uridylation of microRNA directs cytokine expression

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Selective blockade of microRNA processing by Lin28

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The let-7 family of microRNAs

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Lin28 promotes transformation and is associated with advanced human malignancies

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DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs

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Modulation of microRNA processing by p53

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SMAD proteins control DROSHA-mediated microRNA maturation

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The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis

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Regulation of cyclin D1 RNA stability by SNIP1

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Nuclear networking fashions pre-messenger RNA and primary microRNA transcripts for function

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Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation

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Ars2 regulates both miRNA- and siRNA- dependent silencing and suppresses RNA virus infection in Drosophila

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Dual roles of the nuclear cap-binding complex and SERRATE in pre-mRNA splicing and microRNA processing in Arabidopsis thaliana

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A splicing-independent function of SF2/ASF in microRNA processing

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Posttranscriptional regulation of miRNAs harboring conserved terminal loops.

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The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs

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The RISC subunit Tudor-SN binds to hyper-edited double-stranded RNA and promotes its cleavage

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RNA editing of the microRNA-151 precursor blocks cleavage by the Dicer-TRBP complex

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Frequency and fate of microRNA editing in human brain

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Editing independent effects of ADARs on the miRNA/siRNA pathways

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Redirection of silencing targets by adenosine-to-inosine editing of miRNAs

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Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway

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Hierarchical rules for Argonaute loading in Drosophila

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Distinct mechanisms for microRNA strand selection by Drosophila Argonautes

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Drosophila argonaute1 and argonaute2 employ distinct mechanisms for translational repression.

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Essential and overlapping functions for mammalian Argonautes in microRNA silencing

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Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing.

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A human snoRNA with microRNA-like functions

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Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP

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A dicer-independent miRNA biogenesis pathway that requires Ago catalysis

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A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity

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A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway

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Importance of translation and nonnucleolytic ago proteins for on-target RNA interference

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Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression.

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HSP90 protein stabilizes unloaded argonaute complexes and microscopic P-bodies in human cells

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GERp95 belongs to a family of signal-transducing proteins and requires Hsp90 activity for stability and Golgi localization

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Prolyl 4-hydroxylation regulates Argonaute 2 stability

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The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2

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Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies

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Relief of microRNA-mediated translational repression in human cells subjected to stress

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microRNAs: a safeguard against turmoil?

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Allosteric regulation of Argonaute proteins by miRNAs.

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An mRNA m7G cap binding-like motif within human Ago2 represses translation

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GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay

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Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes

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The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing

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Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencing

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A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles

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GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation

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Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

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The mechanism of ATP-dependent RNA unwinding by DEAD box proteins

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RNA helicase A interacts with RISC in human cells and functions in RISC loading

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RISC assembly defects in the Drosophila RNAi mutant armitage.

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nhl-2 Modulates microRNA activity in Caenorhabditis elegans

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Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage

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The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors

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Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs

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Hsp90 regulates the function of argonaute 2 and its recruitment to stress granules and P-bodies

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In vitro assembly of plant RNA-induced silencing complexes facilitated by molecular chaperone HSP90.

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Hsc70/Hsp90 chaperone machinery mediates ATP-dependent RISC loading of small RNA duplexes

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RNA-binding protein Dnd1 inhibits microRNA access to target mRNA

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Differential regulation of germline mRNAs in soma and germ cells by zebrafish miR-430.

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The Caenorhabditis elegans pumilio homolog, puf-9, is required for the 3'UTR-mediated repression of the let-7 microRNA target gene, hbl-1

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Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system

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HuR recruits let-7/RISC to repress c-Myc expression

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miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts

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AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2.

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Switching from repression to activation: microRNAs can up-regulate translation

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MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation

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microRNA-122 stimulates translation of hepatitis C virus RNA

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Silencing by small RNAs is linked to endosomal trafficking

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GERp95, a membrane-associated protein that belongs to a family of proteins involved in stem cell differentiation

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Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer

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Cell signalling by microRNA165/6 directs gene dose-dependent root cell fate.

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Cell contact-dependent acquisition of cellular and viral nonautonomously encoded small RNAs

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Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

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Specific and potent RNAi in the nucleus of human cells

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A multifunctional human Argonaute2-specific monoclonal antibody

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CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs.

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A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain

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Transcriptional control of gene expression by microRNAs

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MicroRNA binding sites in Arabidopsis class III HD-ZIP mRNAs are required for methylation of the template chromosome

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DNA methylation mediated by a microRNA pathway

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MicroRNA-directed transcriptional gene silencing in mammalian cells

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Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila

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A coordinated local translational control point at the synapse involving relief from silencing and MOV10 degradation

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A brain-specific microRNA regulates dendritic spine development

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A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis

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Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies

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Dendrites of mammalian neurons contain specialized P-body-like structures that respond to neuronal activation

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Dynamic interaction between P-bodies and transport ribonucleoprotein particles in dendrites of mature hippocampal neurons

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Expression of microRNAs and their precursors in synaptic fractions of adult mouse forebrain

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Macro role(s) of microRNAs in fragile X syndrome?

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Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132

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Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway

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Control of stress-dependent cardiac growth and gene expression by a microRNA

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Integration of microRNA miR-122 in hepatic circadian gene expression

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Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs

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A hexanucleotide element directs microRNA nuclear import.

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Post-transcriptional regulation of miR-27 in murine cytomegalovirus infection

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Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer's disease temporal lobe neocortex

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Characterization of small RNAs in Aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB.

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MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction

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Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo

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Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system

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Selective stabilization of mammalian microRNAs by 3' adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2.

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Adenylation of plant miRNAs.

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Methylation protects miRNAs and siRNAs from a 3'-end uridylation activity in Arabidopsis.

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Degradation of microRNAs by a family of exoribonucleases in Arabidopsis

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Active turnover modulates mature microRNA activity in Caenorhabditis elegans

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Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps

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Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells

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Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites

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Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila

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Chromatin structure analyses identify miRNA promoters

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Features of mammalian microRNA promoters emerge from polymerase II chromatin immunoprecipitation data

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c-Myc-regulated microRNAs modulate E2F1 expression

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miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

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Widespread microRNA repression by Myc contributes to tumorigenesis

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A microRNA component of the p53 tumour suppressor network

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Reciprocal actions of REST and a microRNA promote neuronal identity

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P bodies: at the crossroads of post-transcriptional pathways

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The control of mRNA decapping and P-body formation.

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P bodies and the control of mRNA translation and degradation

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Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54

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P-body formation is a consequence, not the cause, of RNA-mediated gene silencing

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Formation of GW bodies is a consequence of microRNA genesis

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Derepression of microRNA-mediated protein translation inhibition by apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G) and its family members

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MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

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Inhibition of translational initiation by Let-7 MicroRNA in human cells

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Cellular microRNA and P bodies modulate host-HIV-1 interactions

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MicroRNA activity is suppressed in mouse oocytes

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MicroRNA function is globally suppressed in mouse oocytes and early embryos

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P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes

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Dcp1-bodies in mouse oocytes

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Stress granules and processing bodies are dynamically linked sites of mRNP remodeling

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The NF90-NF45 complex functions as a negative regulator in the microRNA processing pathway

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A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA

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Maturation of microRNA is hormonally regulated by a nuclear receptor

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DNA methylation regulates MicroRNA expression

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PubMed

https://pubmed.ncbi.nlm.nih.gov/20661255