Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032. (Q27853187)

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Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032

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English	Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.	scientific article	Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032

Statements

scholarly article

1 reference

PubMed publication ID

13 November 2016

Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032. (English)

1 reference

PubMed publication ID

13 November 2016

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medulloblastoma

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Murali Chintagumpala

11

object named as

Murali Chintagumpala

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object named as

Giles W Robinson

1

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object named as

Tom Curran

21

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18

object named as

Maryam Fouladi

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Annick Desjardins

10

object named as

Annick Desjardins

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Sridharan Gururangan

4

object named as

Sridharan Gururangan

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13

object named as

Sue C Kaste

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Michael D Prados

9

object named as

Michael D Prados

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Clinton F Stewart

17

object named as

Clinton F Stewart

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23

object named as

Amar Gajjar

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Richard Gilbertson

20

object named as

Richard J Gilbertson

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Arzu Onar-Thomas

16

object named as

Arzu Onar-Thomas

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author name string

Brent A Orr

2

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Gang Wu

3

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Tong Lin

5

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Ibrahim Qaddoumi

6

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Roger J Packer

7

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Stewart Goldman

8

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Naoko Takebe

12

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Michael Rusch

14

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Sariah J Allen

15

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James M Boyett

19

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David W Ellison

22

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language of work or name

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publication date

20 August 2015

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Journal of Clinical Oncology

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33

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24

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2646-54

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Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

1 reference

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20 March 2017

Dissecting the genomic complexity underlying medulloblastoma

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20 March 2017

Molecular subgroups of medulloblastoma: the current consensus

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

20 March 2017

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

20 March 2017

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

20 March 2017

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

20 March 2017

Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

24 May 2017

The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

29 September 2017

Cytogenetic prognostication within medulloblastoma subgroups

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

29 September 2017

Phase I study of vismodegib in children with recurrent or refractory medulloblastoma: a pediatric brain tumor consortium study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

29 September 2017

Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

29 September 2017

Novel mutations target distinct subgroups of medulloblastoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

29 September 2017

Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

29 September 2017

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

29 September 2017

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

29 September 2017

Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

29 September 2017

Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

29 September 2017

Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

29 September 2017

Definition of Disease-Risk Stratification Groups in Childhood Medulloblastoma Using Combined Clinical, Pathologic, and Molecular Variables

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

29 September 2017

Medulloblastoma comprises four distinct molecular variants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

29 September 2017

Long-term outcomes among adult survivors of childhood central nervous system malignancies in the Childhood Cancer Survivor Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

29 September 2017

Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

29 September 2017

A phase I, multicenter, open-label, first-in-human, dose-escalation study of the oral smoothened inhibitor Sonidegib (LDE225) in patients with advanced solid tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

2 June 2018

PTEN loss mitigates the response of medulloblastoma to Hedgehog pathway inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

2 June 2018

Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

2 June 2018

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

2 June 2018

Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

27 November 2018

Universal poor survival in children with medulloblastoma harboring somatic TP53 mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

27 November 2018

Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

27 November 2018

Loss of suppressor-of-fused function promotes tumorigenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

27 November 2018

Neurocognitive consequences of risk-adapted therapy for childhood medulloblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

27 November 2018

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4534527

27 November 2018

Identifiers

10.1200/JCO.2014.60.1591

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PubMed publication ID

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OpenCitations bibliographic resource ID

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