The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate (Q27748902)

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English	The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate	scientific article

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9 November 2019

The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate (English)

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9 November 2019

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crystal structure

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3

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9 November 2019

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A E Aleshin

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9 November 2019

C Zeng

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9 November 2019

H D Bartunik

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9 November 2019

H J Fromm

5

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9 November 2019

R B Honzatko

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9 November 2019

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1 January 1998

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9 November 2019

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9 November 2019

6

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9 November 2019

1

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9 November 2019

39-50

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9 November 2019

Multiple forms of hexokinase in the rat: tissue distribution, age dependency, and properties

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

1 reference

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7 January 2021

based on heuristic

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Purification and properties of pig-heart hexokinase

1 reference

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7 January 2021

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Purification and properties of rat skeletal muscle hexokinase

1 reference

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7 January 2021

based on heuristic

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Inhibition of brain hexokinase by a multisubstrate analog results from binding to a discrete regulatory site.

1 reference

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7 January 2021

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Isolation and characterization of the discrete N- and C-terminal halves of rat brain hexokinase: retention of full catalytic activity in the isolated C-terminal half

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900006-9

7 January 2021

based on heuristic

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Active site residues of human brain hexokinase as studied by site-specific mutagenesis

1 reference

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7 January 2021

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Functional organization of mammalian hexokinases: both N- and C-terminal halves of the rat type II isozyme possess catalytic sites

1 reference

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Structure of a complex between yeast hexokinase A and glucose. I. Structure determination and refinement at 3.5 A resolution

1 reference

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7 January 2021

based on heuristic

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Rat brain hexokinase: location of the allosteric regulatory site in a structural domain at the N-terminus of the enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900006-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Kinetic evidence that the high-affinity glucose 6-phosphate site on hexokinase I Is the active site

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900006-9

7 January 2021

based on heuristic

inferred from DOI database lookup

PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900006-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of a complex between yeast hexokinase A and glucose. II. Detailed comparisons of conformation and active site configuration with the native hexokinase B monomer and dimer

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900006-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Rat brain hexokinase: glucose and glucose-6-phosphate binding sites and C-terminal amino acid of the purified enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900006-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Mapping of glucose and glucose-6-phosphate binding sites on bovine brain hexokinase. A 1H- and 31P-NMR investigation

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900006-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Specificity for the glucose-6-P inhibition site of hexokinase

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900006-9

7 January 2021

based on heuristic

inferred from DOI database lookup

A recombinant human ‘mini’-hexokinase is catalytically active and regulated by hexose 6-phosphates

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900006-9

7 January 2021

based on heuristic

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Residues Putatively Involved in Binding of ATP and Glucose 6-Phosphate to a Mammalian Hexokinase: Site-Directed Mutation at Analogous Positions in the N- and C-Terminal Halves of the Type I Isozyme

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900006-9

7 January 2021

based on heuristic

inferred from DOI database lookup

ATP-binding site of human brain hexokinase as studied by molecular modeling and site-directed mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900006-9

7 January 2021

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An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins

1 reference

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7 January 2021

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Structure of the regulatory complex of Escherichia coli IIIGlc with glycerol kinase

1 reference

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7 January 2021

based on heuristic

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Crystallographic studies and model building of ATP at the active site of hexokinase

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900006-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Rat brain hexokinase: location of the substrate nucleotide binding site in a structural domain at the C-terminus of the enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900006-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Complete amino acid sequence of rat brain hexokinase, deduced from the cloned cDNA, and proposed structure of a mammalian hexokinase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of human brain hexokinase in Escherichia coli: purification and characterization of the expressed enzyme

1 reference

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7 January 2021

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inferred from DOI database lookup

The CCP4 suite: programs for protein crystallography

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900006-9

7 January 2021

based on heuristic

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The detection of sub-units within the crystallographic asymmetric unit

1 reference

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7 January 2021

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AMoRe: an automated package for molecular replacement

1 reference

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7 January 2021

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Accurate bond and angle parameters for X-ray protein structure refinement

1 reference

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7 January 2021

based on heuristic

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Human hexokinase: sequences of amino- and carboxyl-terminal halves are homologous

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900006-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Complete nucleotide sequence of the hexokinase PI gene (HXK1) of Saccharomyces cerevisiae

1 reference

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7 January 2021

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

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inferred from DOI database lookup

Identifiers

10.1016/S0969-2126(98)00006-9

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9493266%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9493266%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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