Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein (Q27731423)

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J P Noel

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H E Hamm

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P B Sigler

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language of work or name

English

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publication date

23 June 1994

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published in

Nature

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volume

369

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issue

6482

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page(s)

621-8

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Diversity of G proteins in signal transduction

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Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors

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Signal transduction enzymes of vertebrate photoreceptors

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Interactions of a G-protein with its effector: transducin and cGMP phosphodiesterase in retinal rods

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The GTPase superfamily: a conserved switch for diverse cell functions

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Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

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Crystal structure of an active form of RAS protein, a complex of a GTP analog and the HRAS p21 catalytic domain

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Crystal structures at 2.2 A resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP

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Structure of the GDP domain of EF-Tu and location of the amino acids homologous to ras oncogene proteins

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Crystal structure of active elongation factor Tu reveals major domain rearrangements

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The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S

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Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride

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Tryptophan207 is involved in the GTP-dependent conformational switch in the alpha subunit of the G protein transducin: chymotryptic digestion patterns of the GTP gamma S and GDP-bound forms.

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A mutation that prevents GTP-dependent activation of the alpha chain of Gs.

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Interactions among the subunits of the G protein involved in Saccharomyces cerevisiae mating.

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G-protein alpha o subunit: mutation of conserved cysteines identifies a subunit contact surface and alters GDP affinity

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A site on rod G protein alpha subunit that mediates effector activation

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Identification of effector-activating residues of Gs alpha

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50 Transducin and the cyclic GMP phosphodiesterase of retinal rod outer segments

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Improved methods for building protein models in electron density maps and the location of errors in these models

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A graphics model building and refinement system for macromolecules

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GTPase of bovine rod outer segments: the amino acid sequence of the alpha subunit as derived from the cDNA sequence

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Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase

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Primary structure of the alpha-subunit of bovine adenylate cyclase-inhibiting G-protein deduced from the cDNA sequence

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Deduced amino acid sequence of bovine retinal Go alpha: similarities to other guanine nucleotide-binding proteins

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G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates

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Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin

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Occurrence in Saccharomyces cerevisiae of a gene homologous to the cDNA coding for the alpha subunit of mammalian G proteins

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Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue

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Guanine nucleotide binding characteristics of transducin: essential role of rhodopsin for rapid exchange of guanine nucleotides

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Refined structure of elongation factor EF-Tu from Escherichia coli

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