Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction (Q27680560)

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29 February 2020

title

Transient protein states in designing inhibitors of the MDM2-p53 interaction (English)

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0 references

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29 February 2020

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29 February 2020

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29 February 2020

Siglinde Wolf

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29 February 2020

Kareem Khoury

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29 February 2020

Kaja Kowalska

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29 February 2020

Yijun Huang

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29 February 2020

Ewa Wrona

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29 February 2020

Grzegorz M Popowicz

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29 February 2020

Tad A Holak

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29 February 2020

publication date

24 October 2013

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29 February 2020

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volume

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issue

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page(s)

2143-2151

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Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

29 February 2020

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20 March 2017

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The alpha-helical FXXPhiPhi motif in p53: TAF interaction and discrimination by MDM2

20 March 2017

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

20 March 2017

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20 March 2017

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20 March 2017

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Improved sensitivity of HSQC spectra of exchanging protons at short interscan delays using a new fast HSQC (FHSQC) detection scheme that avoids water saturation

7 April 2017

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29 September 2017

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Interrogation of MDM2 phosphorylation in p53 activation using native chemical ligation: the functional role of Ser17 phosphorylation in MDM2 reexamined

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Quantitative lid dynamics of MDM2 reveals differential ligand binding modes of the p53-binding cleft.

2 June 2018

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2 June 2018

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Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery.

2 June 2018

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27 November 2018

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High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx

27 November 2018

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Targeting the conformational transitions of MDM2 and MDMX: insights into dissimilarities and similarities of p53 recognition.

27 November 2018

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Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53

27 November 2018

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An exact mathematical expression for describing competitive binding of two different ligands to a protein molecule.

27 November 2018

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Aromatic-aromatic interactions in the formation of the MDM2-p53 complex

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24207125

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Multiple peptide conformations give rise to similar binding affinities: molecular simulations of p53-MDM2

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24207125

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

An NMR-based antagonist induced dissociation assay for targeting the ligand-protein and protein-protein interactions in competition binding experiments

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24207125

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.STR.2013.09.006

2 references

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29 February 2020

1 reference

2 references

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29 February 2020

PubMed publication ID

24207125

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24207125%20AND%20SRC:MED&resulttype=core&format=json