Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication (Q27661671)

object named as

Barbara Van Remoortel

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Marc De Maeyer

object named as

Marc De Maeyer

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Frauke Christ

object named as

Frauke Christ

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author name string

Arnout Voet

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Arnaud Marchand

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Stefan Nicolet

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Belete A Desimmie

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Damien Marchand

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Dorothée Bardiot

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Nam Joo Van der Veken

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Barbara Van Remoortel

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Sergei V Strelkov

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Patrick Chaltin

In search of authentic inhibitors of HIV-1 integration

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language of work or name

English

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publication date

June 2010

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published in

Nature Chemical Biology

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volume

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issue

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page(s)

442-8

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cites work

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.370

Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.370

Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation

21 January 2018

1 reference

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Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

1 reference

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Cellular co-factors of HIV-1 integration

1 reference

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Lens epithelium-derived growth factor: effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts

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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

1 reference

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Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin

1 reference

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Update of the drug resistance mutations in HIV-1: 2007.

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Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes.

1 reference

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Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75.

1 reference

12 December 2020

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

1 reference

12 December 2020

HIV-1 integrase preassembled on donor DNA is refractory to activity stimulation by LEDGF/p75.

1 reference

12 December 2020

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

1 reference

12 December 2020

D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75.

1 reference

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

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MDM2 inhibitors for cancer therapy

1 reference

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Development and validation of a genetic algorithm for flexible docking

1 reference

12 December 2020

Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75

1 reference

12 December 2020

Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors

1 reference

12 December 2020

Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain

1 reference

12 December 2020

Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication

1 reference

12 December 2020

Protein-protein interactions in human disease

1 reference

12 December 2020

Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)

1 reference

12 December 2020

LEDGF/p75: a novel nuclear autoantigen at the crossroads of cell survival and apoptosis

1 reference

12 December 2020

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

12 December 2020

Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases

1 reference

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Inhibitors of human immunodeficiency virus type I integration

1 reference

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Wild-type levels of human immunodeficiency virus type 1 infectivity in the absence of cellular emerin protein

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Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ.

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Structural details on mdm2-p53 interaction

1 reference

12 December 2020

HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

1 reference

12 December 2020

The CCP4 suite: programs for protein crystallography

1 reference

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Novel targets for HIV therapy

1 reference

12 December 2020

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

1 reference

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Novel HIV-1 integrase inhibitors derived from quinolone antibiotics

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Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection

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Identification of the LEDGF/p75 binding site in HIV-1 integrase

1 reference

12 December 2020

A role for LEDGF/p75 in targeting HIV DNA integration

1 reference

12 December 2020

The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation

1 reference

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Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases

1 reference

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Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells

1 reference

12 December 2020

The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication

1 reference

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Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering

1 reference

12 December 2020

Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro

1 reference

12 December 2020

Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase

1 reference

12 December 2020

Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication

1 reference

12 December 2020

Knowledge-based scoring function to predict protein-ligand interactions.

1 reference

12 December 2020

An essential role for LEDGF/p75 in HIV integration

1 reference

12 December 2020