Hsp70 family ATPase KAR2 YJL034W (Q27551305)

Heat shock protein 70kD, C-terminal domain superfamily

1 reference

Heat shock protein 70 family

1 reference

inferred from GOA cell component → membrane

membrane protein

1 reference

based on heuristic

Heat shock protein 70, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16474&geneProductId=UniProtKB:P16474

1 reference

27 March 2018

ATPase activity

1 reference

27 March 2018

Purification and characterization of BiP/Kar2 protein from Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16474&geneProductId=UniProtKB:P16474

unfolded protein binding

2 references

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16474

1 reference

14 February 2019

ATPase activity

heat shock protein binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16474

protein folding chaperone activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16474

unfolded protein binding

Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins.

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16474

14 February 2019

Futile protein folding cycles in the ER are terminated by the unfolded protein O-mannosylation pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16474

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16474

misfolded protein binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16474

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16474

1 reference

14 February 2019

luminal surveillance complex

cell component

1 reference

14 February 2019

A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16474

endoplasmic reticulum lumen

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16474&geneProductId=UniProtKB:P16474

1 reference

27 March 2018

nucleus

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16474

cytoplasm

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16474

membrane

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16474

endoplasmic reticulum chaperone complex

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16474

posttranslational protein targeting to membrane, translocation

biological process

response to unfolded protein

2 references

1 reference

27 March 2018

Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16474&geneProductId=UniProtKB:P16474

SRP-dependent cotranslational protein targeting to membrane, translocation

1 reference

14 February 2019

BiP and Sec63p are required for both co- and posttranslational protein translocation into the yeast endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16474

ubiquitin-dependent ERAD pathway

1 reference

27 March 2018

Molecular chaperones in the yeast endoplasmic reticulum maintain the solubility of proteins for retrotranslocation and degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16474&geneProductId=UniProtKB:P16474

karyogamy involved in conjugation with cellular fusion

1 reference

14 February 2019

Genetic interactions between KAR7/SEC71, KAR8/JEM1, KAR5, and KAR2 during nuclear fusion in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16474

fungal-type cell wall beta-glucan biosynthetic process

IGI

1 reference

14 February 2019

Cell wall 1,6-beta-glucan synthesis in Saccharomyces cerevisiae depends on ER glucosidases I and II, and the molecular chaperone BiP/Kar2p

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16474

response to unfolded protein

IGI

ubiquitin-dependent ERAD pathway

endoplasmic reticulum unfolded protein response

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16474

cellular response to heat

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16474

Unfolded Protein Response

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16474

protein refolding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16474

chaperone cofactor-dependent protein refolding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16474

Heat shock protein 70, conserved site

has part(s)

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference