Hepatitis C virus subgenomic replicon requires an active NS3 RNA helicase (Q27472781)

5 July 2017

title

Hepatitis C virus subgenomic replicon requires an active NS3 RNA helicase (English)

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5 July 2017

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David N Frick

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Angela M I Lam

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5 July 2017

publication date

1 January 2006

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5 July 2017

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5 July 2017

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5 July 2017

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5 July 2017

page(s)

404-411

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Stimulation of hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase activity by the NS3 protease domain and by HCV RNA-dependent RNA polymerase

5 July 2017

cites work

1 reference

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Robust hepatitis C virus infection in vitro

21 March 2017

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Cellular RNA helicase p68 relocalization and interaction with the hepatitis C virus (HCV) NS5B protein and the potential role of p68 in HCV RNA replication

21 March 2017

1 reference

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Hepatitis C Virus NS3 ATPases/Helicases from Different Genotypes Exhibit Variations in Enzymatic Properties

21 March 2017

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Structurally conserved amino Acid w501 is required for RNA helicase activity but is not essential for DNA helicase activity of hepatitis C virus NS3 protein.

21 March 2017

1 reference

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Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication

21 March 2017

1 reference

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The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding

21 March 2017

1 reference

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Structure-Based Mutational Analysis of the Hepatitis C Virus NS3 Helicase

21 March 2017

1 reference

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Characterization of cell lines carrying self-replicating hepatitis C virus RNAs

21 March 2017

1 reference

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Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo

21 March 2017

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Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase

21 March 2017

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Structure-based mutagenesis study of hepatitis C virus NS3 helicase

21 March 2017

1 reference

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Crystal structure of RNA helicase from genotype 1b hepatitis C virus. A feasible mechanism of unwinding duplex RNA

21 March 2017

1 reference

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Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding

21 March 2017

1 reference

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Structure of the hepatitis C virus RNA helicase domain

21 March 2017

1 reference

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Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes

21 March 2017

1 reference

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Complete replication of hepatitis C virus in cell culture

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1317551

Efficient initiation of HCV RNA replication in cell culture

21 March 2017

1 reference

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Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1317551

Characterization and mutational analysis of the helicase and NTPase activities of hepatitis C virus full-length NS3 protein

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1317551

Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon

21 March 2017

1 reference

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Genetic interactions between hepatitis C virus replicons.

7 April 2017

1 reference

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Electrostatic analysis of the hepatitis C virus NS3 helicase reveals both active and allosteric site locations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1317551

Enhanced nucleic acid binding to ATP-bound hepatitis C virus NS3 helicase at low pH activates RNA unwinding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1317551

Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1317551

The nonstructural protein 3 protease/helicase requires an intact protease domain to unwind duplex RNA efficiently

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1317551

Two novel conserved motifs in the hepatitis C virus NS3 protein critical for helicase action

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1317551

Hepatitis C virus NS3 RNA helicase activity is modulated by the two domains of NS3 and NS4A.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1317551

Complex formation of NS5B with NS3 and NS4A proteins of hepatitis C virus

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1317551

Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1317551

The RNA-unwinding activity of hepatitis C virus non-structural protein 3 (NS3) is positively modulated by its protease domain

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1317551

Modulation of the hepatitis C virus RNA-dependent RNA polymerase activity by the non-structural (NS) 3 helicase and the NS4B membrane protein.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1317551

Mutational analysis of hepatitis C virus NS3-associated helicase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1317551

Kinetic analysis of the effects of mutagenesis of W501 and V432 of the hepatitis C virus NS3 helicase domain on ATPase and strand-separating activity

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1317551

The helicase from hepatitis C virus is active as an oligomer

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1317551

Functional interactions between conserved motifs of the hepatitis C virus RNA helicase protein NS3.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1317551

DNA helicase activity of the hepatitis C virus nonstructural protein 3.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1317551

10.1128/JVI.80.1.404-411.2006

27 November 2018

Identifiers

DOI

1 reference

release_muudvhmeyjgvlfuncfk3mjduke

5 July 2017

Fatcat ID

0 references

PMC publication ID

1317551

1 reference

5 July 2017

1 reference