Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation (Q27469500)

3 July 2017

title

Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation (English)

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3 July 2017

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M Gale

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3 July 2017

C M Blakely

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3 July 2017

B Kwieciszewski

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3 July 2017

S L Tan

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3 July 2017

M Dossett

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3 July 2017

N M Tang

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3 July 2017

M J Korth

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3 July 2017

S J Polyak

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3 July 2017

D R Gretch

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3 July 2017

M G Katze

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3 July 2017

language of work or name

English

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publication date

1 September 1998

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Molecular and Cellular Biology

3 July 2017

published in

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3 July 2017

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3 July 2017

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3 July 2017

page(s)

5208-5218

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Evolution of hepatitis C virus quasispecies in hypervariable region 1 and the putative interferon sensitivity-determining region during interferon therapy and natural infection.

3 July 2017

cites work

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Hepatitis C virus core from two different genotypes has an oncogenic potential but is not sufficient for transforming primary rat embryo fibroblasts in cooperation with the H-ras oncogene

21 March 2017

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21 March 2017

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Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase

21 March 2017

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Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein

21 March 2017

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Nonstructural protein 3 of hepatitis C virus blocks the distribution of the free catalytic subunit of cyclic AMP-dependent protein kinase

21 March 2017

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21 March 2017

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21 March 2017

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Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo

21 March 2017

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Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region

21 March 2017

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The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins

21 March 2017

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Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

21 March 2017

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Transmission of Hepatitis C by Intrahepatic Inoculation with Transcribed RNA

21 March 2017

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The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

21 March 2017

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Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

21 March 2017

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Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis

21 March 2017

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Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection

21 March 2017

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Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral disease

7 April 2017

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Molecular mechanisms of interferon resistance mediated by viral-directed inhibition of PKR, the interferon-induced protein kinase

7 April 2017

1 reference

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Double-stranded RNA-independent dimerization of interferon-induced protein kinase PKR and inhibition of dimerization by the cellular P58IPK inhibitor

29 September 2017

1 reference

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Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha.

29 September 2017

1 reference

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A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

29 September 2017

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Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR.

29 September 2017

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Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB

29 September 2017

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Suppression of apoptotic cell death by hepatitis C virus core protein

29 September 2017

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Specific mutations near the amino terminus of double-stranded RNA-dependent protein kinase (PKR) differentially affect its double-stranded RNA binding and dimerization properties

29 September 2017

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Interaction of the interferon-induced PKR protein kinase with inhibitory proteins P58IPK and vaccinia virus K3L is mediated by unique domains: implications for kinase regulation

29 September 2017

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Molecular biology and pathogenesis of animal lentivirus infections.

29 September 2017

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Mechanism of interferon action. Biochemical and genetic evidence for the intermolecular association of the RNA-dependent protein kinase PKR from human cells

29 September 2017

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Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

29 September 2017

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Hepatitis C: progress and problems

29 September 2017

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Structural requirements for double-stranded RNA binding, dimerization, and activation of the human eIF-2 alpha kinase DAI in Saccharomyces cerevisiae

29 September 2017

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Interferon-Induced Antiviral Actions and Their Regulation

29 September 2017

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Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109106

PKR: a new name and new roles.

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109106

29 September 2017

Therapy of Hepatitis C

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109106

Epidemiology of Hepatitis C in the West

29 September 2017

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Epidemiology of Hepatitis C in the East

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109106

Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109106

Variability of hepatitis C virus

29 September 2017

1 reference

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Role of the amino-terminal residues of the interferon-induced protein kinase in its activation by double-stranded RNA and heparin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109106

The 58-kilodalton inhibitor of the interferon-induced double-stranded RNA-activated protein kinase is a tetratricopeptide repeat protein with oncogenic properties

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109106

Monoclonal antibodies to an interferon-induced Mr 68,000 protein and their use for the detection of double-stranded RNA-dependent protein kinase in human cells

29 September 2017

1 reference

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Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109106

Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities

29 September 2017

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The war against the interferon-induced dsRNA-activated protein kinase: can viruses win?

29 September 2017

1 reference

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Constitutive expression of human double-stranded RNA-activated p68 kinase in murine cells mediates phosphorylation of eukaryotic initiation factor 2 and partial resistance to encephalomyocarditis virus growth

29 September 2017

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The interferon system. A bird's eye view of its biochemistry

29 September 2017

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The double-stranded RNA-dependent protein kinase PKR: structure and function

29 September 2017

1 reference

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Mutations of hepatitis C virus 1b NS5A 2209-2248 amino acid sequence do not predict the response to recombinant interferon-alfa therapy in French patients

2 June 2018

1 reference

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Sensitization to Fas-mediated apoptosis by hepatitis C virus core protein

2 June 2018

1 reference

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The interferon sensitivity determining region: all hepatitis C virus isolates are not the same

2 June 2018

1 reference

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Analysis of genotypes and amino acid residues 2209 to 2248 of the NS5A region of hepatitis C virus in relation to the response to interferon-beta therapy

2 June 2018

1 reference

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Mutations in the nonstructural 5A gene of European hepatitis C virus isolates and response to interferon alfa

2 June 2018

1 reference

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Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome.

2 June 2018

1 reference

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Molecular mechanisms responsible for malignant transformation by regulatory and catalytic domain variants of the interferon-induced enzyme RNA-dependent protein kinase

2 June 2018

1 reference

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Sequence requirements for coiled-coils: analysis with lambda repressor-GCN4 leucine zipper fusions

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109106

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109106

Cytosolic double-stranded RNA-dependent protein kinase is likely a dimer of partially phosphorylated Mr = 66,000 subunits

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109106

Hepatitis C virus NS5A protein is phosphorylated in vitro by a stably bound protein kinase from HeLa cells and by cAMP-dependent protein kinase A-alpha catalytic subunit

2 June 2018

1 reference

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Mutations in the NS5A gene of hepatitis C virus in North American patients infected with HCV genotype 1a or 1b.

27 November 2018

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Characterization of the solution complex between the interferon-induced, double-stranded RNA-activated protein kinase and HIV-I trans-activating region RNA.

27 November 2018

1 reference

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Pretreatment virus load and multiple amino acid substitutions in the interferon sensitivity-determining region predict the outcome of interferon treatment in patients with chronic genotype 1b hepatitis C virus infection

27 November 2018

1 reference

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Factors predictive of response to interferon-alpha therapy in hepatitis C virus infection

27 November 2018

1 reference

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Evaluation of complete genome sequences and sequences of individual gene products for the classification of hepatitis C viruses

27 November 2018

1 reference

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Hepatitis C and Hepatocellular Carcinoma

27 November 2018

1 reference

12 December 2020

Repressor fusions as a tool to study protein–protein interactions

1 reference

12 December 2020

The kinase insert domain of interferon-induced protein kinase PKR is required for activity but not for interaction with the pseudosubstrate K3L

1 reference

12 December 2020

The 58-kDa cellular inhibitor of the double stranded RNA-dependent protein kinase requires the tetratricopeptide repeat 6 and DnaJ motifs to stimulate protein synthesis in vivo

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12 December 2020

Identifiers

DOI

10.1128/MCB.18.9.5208

1 reference

OpenCitations bibliographic resource ID

3 July 2017

2141709

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2141709

1 reference