sofosbuvir (Q2502747)

SOFOSBUVIR (English)

L-Alanine, N-[[P(R),2′R]-2′-deoxy-2′-fluoro-2′-methyl-P-phenyl-5′-uridylyl]-, 1-methylethyl ester

3 October 2016

discoverer or inventor

Michael J. Sofia

0 references

stereoisomer of

1 reference

based on heuristic

inferred from InChI

chemical formula

C₂₂H₂₉FN₃O₉P

1 reference

PSI-7977 (English)

19 November 2016

CC(C)OC(=O)C(C)NP(=O)(OCC1C(C(C(O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3

1 reference

PSI-7977 (English)

19 November 2016

C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3

1 reference

https://www.whocc.no/atc_ddd_index/?code=J05AX15

PSI-7977 (English)

19 November 2016

0.4 gram

route of administration

oral administration

1 reference

reference URL

1 reference

14 February 2018

sofosbuvir/velpatasvir

1 reference

European Medicines Agency product number

EMEA/H/C/004210

medical condition treated

hepatitis C

1 reference

Drug Indications Extracted from FAERS

2 October 2018

hepatitis

1 reference

Drug Indications Extracted from FAERS

2 October 2018

liver cirrhosis

1 reference

Drug Indications Extracted from FAERS

significant drug interaction

2 October 2018

amiodarone

side effect

sinus bradycardia

1 reference

sourcing circumstances

established

A reference set of clinically relevant adverse drug-drug interactions

amiodarone

side effect

atrioventricular block

1 reference

sourcing circumstances

established

A reference set of clinically relevant adverse drug-drug interactions

legal status (medicine)

boxed warning

1 reference

reference URL

https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802

imported from Wikimedia project

FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (English)

pregnancy category

US pregnancy category B

1 reference

English Wikipedia

LiverTox likelihood score

LiverTox toxicity likelihood category E*

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Sofosbuvir

last update

10 January 2018

official website

http://www.sovaldi.com/

1 reference

imported from Wikimedia project

1 reference

Medical Subject Headings

15 March 2018

0 references

0 references

1 reference

2 references

on focus list of Wikimedia project

WikiProject Zika Corpus

0 references

0 references

0 references

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Sofosbuvir

0 references

catalog

CAS COVID-19 Anti-Viral Candidate Compounds

0 references

Identifiers

InChI

InChI=1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16+,18+,20+,22+,36-/m0/s1

1 reference

PSI-7977 (English)

19 November 2016

2 references

PSI-7977 (English)

19 November 2016

ChEBI release 2020-09-01

CAS Registry Number

1190307-88-0

2 references

Global Substance Registration System

UNII

WJ6CA3ZU8B

sofosbuvir (English)

19 November 2016

https://commonchemistry.cas.org/detail?cas_rn=1190307-88-0

9 April 2021

1 reference

Sofosbuvir (English)

19 November 2016

2 references

PSI-7977 (English)

19 November 2016

InChIKey

Reaxys registry number

20867484

1 reference

sofosbuvir (English)

3 October 2016

mapping relation type

2 references

SOFOSBUVIR (English)

19 November 2016

International Chemical Identifier

1 reference

SOFOSBUVIR (English)

19 November 2016

1 reference

InChIKey

Hazardous Substances Data Bank

1 reference

1 reference

28 October 2019

Sofosbuvir (English)

10 May 2021

1 reference

InChIKey

LiverTox ID

Sofosbuvir

0 references

EC number

695-717-4

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.224.393

27 December 2018

ECHA Substance Infocard ID

Isopropyl (2S)-2-{[(S)-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-4-fluoro-3-hydroxy-4-methyltetrahydro-2-furanyl]methoxy}(phenoxy)phosphoryl]amino}propanoate (English)

quotation

CAS no.: 1190307-88-0 (English)

100.224.393

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.224.393

27 December 2018

Isopropyl (2S)-2-{[(S)-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-4-fluoro-3-hydroxy-4-methyltetrahydro-2-furanyl]methoxy}(phenoxy)phosphoryl]amino}propanoate (English)

quotation

CAS no.: 1190307-88-0 (English)

1 reference