Structural definition of a conserved neutralization epitope on HIV-1 gp120 (Q24655948)

Gary J Nabel

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Peter D. Kwong

Peter D Kwong

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Dennis R. Burton

Dennis R Burton

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Tongqing Zhou

Tongqing Zhou

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James Arthos

James Arthos

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Richard T. Wyatt

Richard Wyatt

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Ann J Hessell

Ann J Hessell

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Mei-Yun Zhang

Mei-Yun Zhang

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Sutapa Dey Barna

Barna Dey

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Donald Van Ryk

Donald Van Ryk

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Xinzhen Yang

Xinzhen Yang

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author name string

Ling Xu

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Shi-Hua Xiang

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Michael B Zwick

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Dimiter S Dimitrov

Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design

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language of work or name

English

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publication date

15 February 2007

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published in

Nature

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volume

445

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issue

7129

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page(s)

732-7

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cites work

1 reference

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Structural evidence for recognition of a single epitope by two distinct antibodies

7 April 2017

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Specific chemical and structural damage to proteins produced by synchrotron radiation

7 April 2017

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Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

7 April 2017

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Atomic structure of the ectodomain from HIV-1 gp41

7 April 2017

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Core structure of gp41 from the HIV envelope glycoprotein

7 April 2017

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7 April 2017

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HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

7 April 2017

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Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120.

7 April 2017

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Timing the ancestor of the HIV-1 pandemic strains

7 April 2017

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The antigenic structure of the HIV gp120 envelope glycoprotein

7 April 2017

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The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

7 April 2017

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Structure of a human common cold virus and functional relationship to other picornaviruses

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Antibody neutralization and escape by HIV-1

7 April 2017

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Structure of an unliganded simian immunodeficiency virus gp120 core

7 April 2017

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HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

7 April 2017

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The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens

7 April 2017

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Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1

7 April 2017

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7 April 2017

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7 January 2021

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Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody

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Restraining the conformation of HIV-1 gp120 by removing a flexible loop

7 April 2017

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Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibody

28 September 2017

1 reference

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A human T-cell leukemia virus type 1 regulatory element enhances the immunogenicity of human immunodeficiency virus type 1 DNA vaccines in mice and nonhuman primates

28 September 2017

1 reference

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Characterization of the outer domain of the gp120 glycoprotein from human immunodeficiency virus type 1

28 September 2017

1 reference

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Improved breadth and potency of an HIV-1-neutralizing human single-chain antibody by random mutagenesis and sequential antigen panning

28 September 2017

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Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120.

28 September 2017

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Molecular recognition in antibody-antigen complexes

28 September 2017

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Antibodies, viruses and vaccines

28 September 2017

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Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro

28 September 2017

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The neutralizing antibody response to HIV-1: viral evasion and escape from humoral immunity

28 September 2017

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Effects of N-butyldeoxynojirimycin and the Lec3.2.8.1 mutant phenotype on N-glycan processing in Chinese hamster ovary cells: application to glycoprotein crystallization.

28 September 2017

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Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding

28 September 2017

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Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG.

28 September 2017

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Identification and characterization of conserved and variable regions in the envelope gene of HTLV-III/LAV, the retrovirus of AIDS.

28 September 2017

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28 September 2017

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Neutralization of human T-lymphotropic virus type III by sera of AIDS and AIDS-risk patients

30 May 2018

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Epitopes recognized by the neutralizing antibodies of an HIV-1-infected individual

30 May 2018

1 reference

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Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody.

30 May 2018

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Biochemical and biological characterization of a dodecameric CD4-Ig fusion protein: implications for therapeutic and vaccine strategies

28 November 2018

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Probability analysis of variational crystallization and its application to gp120, the exterior envelope glycoprotein of type 1 human immunodeficiency virus (HIV-1).

28 November 2018

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A trimeric structural domain of the HIV-1 transmembrane glycoprotein.

28 November 2018

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Processing of X-ray diffraction data collected in oscillation mode

28 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/17301785

12 December 2020

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Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation

1 reference

PubMed

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Enhancement or inhibition of HIV-1 replication by intracellular expression of sense or antisense RNA targeted at different intermediates of reverse transcription

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https://api.crossref.org/works/10.1038%2FNATURE05580

7 January 2021

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AMoRe: an automated package for molecular replacement

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Crossref

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7 January 2021

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Identifiers

DOI

10.1038/NATURE05580

1 reference

Dimensions Publication ID

1021005596

0 references

1 reference

1 reference

PubMed publication ID

17301785

1 reference