Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors (Q24647779)

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7 January 2020

title

Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors (English)

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7 January 2020

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7 January 2020

Sébastien Guery

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7 January 2020

Philipp Floersheim

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7 January 2020

Wolfgang Froestl

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7 January 2020

language of work or name

English

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publication date

8 September 2007

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Bioorganic & Medicinal Chemistry Letters

7 January 2020

published in

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7 January 2020

volume

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7 January 2020

issue

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7 January 2020

page(s)

6206-6211

1 reference

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Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501

7 January 2020

cites work

2 references

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7 January 2021

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Is the GABA B heterodimer a good drug target?

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Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression.

28 September 2017

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Molecular structure and physiological functions of GABA(B) receptors

28 September 2017

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Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines

28 September 2017

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N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function.

28 September 2017

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Potent and selective ET-A antagonists. 1. Syntheses and structure-activity relationships of N-(6-(2-(aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide derivatives

28 September 2017

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The in vitro micronucleus technique

28 September 2017

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Mutagenicity of nitroaromatic compounds

28 September 2017

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(-)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor.

28 September 2017

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Reductive activation of nitroheterocyclic compounds

28 September 2017

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Mini mutagenicity test: a miniaturized version of the Ames test used in a prescreening assay for point mutagenesis assessment

28 September 2017

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Improved synthesis of 2,2'-bipyrimidine.

30 May 2018

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Structural studies on bioactive compounds. Part 29: palladium catalysed arylations and alkynylations of sterically hindered immunomodulatory 2-amino-5-halo-4,6-(disubstituted)pyrimidines

28 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/17884493

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12 December 2020

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Comparative evaluation of the in vitro micronucleus test and the in vitro chromosome aberration test: industrial experience

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Identifiers

DOI

10.1016/J.BMCL.2007.09.023

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17884493%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

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7 January 2020

PubMed publication ID

17884493

1 reference

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