Paths reunited: Initiation of the classical and lectin pathways of complement activation (Q24646047)

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Daniel A Mitchell

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Ralf Schmid

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Wilhelm J Schwaeble

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Anthony H Keeble

Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins

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language of work or name

English

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publication date

2010

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published in

Immunobiology

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volume

215

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issue

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page(s)

1-11

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cites work

1 reference

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Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: structure of the active catalytic region of C1r

7 April 2017

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The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties

7 April 2017

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X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement

7 April 2017

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Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2

7 April 2017

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MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway

7 April 2017

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Structure of a serpin-protease complex shows inhibition by deformation

7 April 2017

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A second serine protease associated with mannan-binding lectin that activates complement

7 April 2017

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MASP-1, a promiscuous complement protease: structure of its catalytic region reveals the basis of its broad specificity

7 April 2017

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C1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational disease

7 April 2017

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Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2

7 April 2017

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The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex

7 April 2017

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Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype

7 April 2017

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The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases

7 April 2017

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The lectin-complement pathway--its role in innate immunity and evolution

7 April 2017

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Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases

7 April 2017

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Stoichiometry of complexes between mannose-binding protein and its associated serine proteases. Defining functional units for complement activation

7 April 2017

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Molecular determinants of oligomer formation and complement fixation in mannose-binding proteins

7 April 2017

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BIOLOGICAL ACTIVITIES OF C1 INHIBITOR

7 April 2017

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Analogous interactions in initiating complexes of the classical and lectin pathways of complement

7 April 2017

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Early complement proteases: C1r, C1s and MASPs. A structural insight into activation and functions

27 September 2017

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Identification of the C1q-binding Sites of Human C1r and C1s: a refined three-dimensional model of the C1 complex of complement

27 September 2017

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C1-inhibitor deficiency and angioedema: molecular mechanisms and clinical progress

27 September 2017

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Assembly of C1 and the MBL- and ficolin-MASP complexes: structural insights.

27 September 2017

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Complement deficiencies in humans and animals: links to autoimmunity

27 September 2017

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Complement: a unique innate immune sensor for danger signals

27 September 2017

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The complement system in regulation of adaptive immunity

27 September 2017

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The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions

27 September 2017

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Structure and activation of the C1 complex of complement: unraveling the puzzle.

27 September 2017

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The X-ray structure of human mannan-binding lectin-associated protein 19 (MAp19) and its interaction site with mannan-binding lectin and L-ficolin

27 September 2017

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Proteases of the complement system

27 September 2017

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Chromatographic resolution of the first component of human complement into three activities

27 September 2017

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Clinical potential of mannose-binding lectin-replacement therapy

27 September 2017

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The mannan-binding lectin-associated serine proteases (MASPs) and MAp19: four components of the lectin pathway activation complex encoded by two genes

27 September 2017

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A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo

27 September 2017

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Up-regulated production and activation of the complement system in Alzheimer's disease brain

27 September 2017

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C1q knock-out mice for the study of complement deficiency in autoimmune disease

27 September 2017

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Baculovirus-mediated expression of truncated modular fragments from the catalytic region of human complement serine protease C1s. Evidence for the involvement of both complement control protein modules in the recognition of the C4 protein substrate

27 September 2017

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Ultrastructure of the first component of human complement: electron microscopy of the crosslinked complex

27 September 2017

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Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease

27 September 2017

1 reference

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Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene

27 September 2017

1 reference

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Serum lectin with known structure activates complement through the classical pathway.

30 May 2018

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Molecular modelling of human complement subcomponent C1q and its complex with C1r2C1s2 derived from neutron-scattering curves and hydrodynamic properties

30 May 2018

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The quaternary structure in solution of human complement subcomponent C1r2C1s2.

30 May 2018

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The unactivated form of the first component of human complement, C1

30 May 2018

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Subunit composition and structure of subcomponent C1q of the first component of human complement

30 May 2018

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Small mannose-binding lectin-associated protein plays a regulatory role in the lectin complement pathway.

30 May 2018

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Functional characterization of complement proteases C1s/mannan-binding lectin-associated serine protease-2 (MASP-2) chimeras reveals the higher C4 recognition efficacy of the MASP-2 complement control protein modules.

28 November 2018

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A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations

28 November 2018

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Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

28 November 2018

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Activation of the C4 and C2 components of complement by a proteinase in serum bactericidal factor, Ra reactive factor

28 November 2018

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Spontaneous activation of the first component of human complement (C1) by an intramolecular autocatalytic mechanism

28 November 2018

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Kinetics of reaction of human C-inhibitor with the human complement system proteases Cr and Cs

28 November 2018

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The biochemistry of complement

28 November 2018

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12 December 2020

Demonstration of the interaction of native C1 with monomeric immunoglobulins and C1 inhibitor

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12 December 2020

Binding of the pentamer/hexamer forms of mannan-binding protein to zymosan activates the proenzyme C1r2C1s2 complex, of the classical pathway of complement, without involvement of C1q

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12 December 2020

Complement deficiencies

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12 December 2020

Activation of complement component C5: comparison of C5 convertases of the lectin pathway and the classical pathway of complement

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12 December 2020

Mannan-Binding Lectin: Structure, Oligomerization, and Flexibility Studied by Atomic Force Microscopy

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12 December 2020

Complement in inflammatory tissue damage and disease

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On the site of C4 deposition upon complement activation via the mannan-binding lectin pathway or the classical pathway

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12 December 2020

10.1016/J.IMBIO.2009.08.006

Identifiers

DOI

1 reference

1 reference

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PubMed publication ID

19783065

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