Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulum (Q24600792)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20519439%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

title

Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulum (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20519439%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

main subject

cell biology

0 references

endoplasmic reticulum

0 references

1 reference

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4 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20519439%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Shuyu Li

1 reference

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4 February 2020

Robert A Spooner

1 reference

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4 February 2020

Stuart C H Allen

1 reference

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4 February 2020

Tina Schnöder

1 reference

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4 February 2020

Manfred J Schmitt

1 reference

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4 February 2020

J Michael Lord

1 reference

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4 February 2020

Lynne M Roberts

1 reference

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4 February 2020

language of work or name

English

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publication date

2 June 2010

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Molecular Biology of the Cell

4 February 2020

published in

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4 February 2020

volume

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4 February 2020

issue

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4 February 2020

page(s)

2543-2554

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Ricin A chain insertion into endoplasmic reticulum membranes is triggered by a temperature increase to 37 {degrees}C

4 February 2020

cites work

1 reference

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Mammalian OS-9 is upregulated in response to endoplasmic reticulum stress and facilitates ubiquitination of misfolded glycoproteins

7 April 2017

1 reference

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Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum

7 April 2017

1 reference

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OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD

7 April 2017

1 reference

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Retrograde transport pathways utilised by viruses and protein toxins

7 April 2017

1 reference

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Protein disulphide-isomerase reduces ricin to its A and B chains in the endoplasmic reticulum

7 April 2017

1 reference

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Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control

7 April 2017

1 reference

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Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains

7 April 2017

1 reference

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The isolation and characterization of temperature-dependent ricin A chain molecules in Saccharomyces cerevisiae

7 April 2017

1 reference

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A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae

7 April 2017

1 reference

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Degradation of a cytosolic protein requires endoplasmic reticulum-associated degradation machinery.

7 April 2017

1 reference

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Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo

7 April 2017

1 reference

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A proteasomal ATPase contributes to dislocation of endoplasmic reticulum-associated degradation (ERAD) substrates.

7 April 2017

1 reference

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Sel1p/Ubx2p participates in a distinct Cdc48p-dependent endoplasmic reticulum-associated degradation pathway

7 April 2017

1 reference

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Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins

7 April 2017

1 reference

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A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation

7 April 2017

1 reference

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The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912342

A genomic screen identifies Dsk2p and Rad23p as essential components of ER-associated degradation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912342

Der1p, a protein required for degradation of malfolded soluble proteins of the endoplasmic reticulum: topology and Der1-like proteins

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912342

An HRD/DER-independent ER quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport

7 April 2017

1 reference

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Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912342

AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation

7 April 2017

1 reference

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The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912342

HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912342

Distinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding

7 April 2017

1 reference

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The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release

7 April 2017

1 reference

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Molecular chaperones in the yeast endoplasmic reticulum maintain the solubility of proteins for retrotranslocation and degradation

7 April 2017

1 reference

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Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome

7 April 2017

1 reference

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Role of Cue1p in ubiquitination and degradation at the ER surface

7 April 2017

1 reference

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Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast

7 April 2017

1 reference

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SEC12 encodes a guanine-nucleotide-exchange factor essential for transport vesicle budding from the ER.

7 April 2017

1 reference

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The yeast gene ERG6 is required for normal membrane function but is not essential for biosynthesis of the cell-cycle-sparking sterol

7 April 2017

1 reference

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ERAD: the long road to destruction

7 April 2017

1 reference

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Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle

7 April 2017

1 reference

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S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase

7 April 2017

1 reference

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Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912342

Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912342

Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912342

Intrinsic conformational determinants signal protein misfolding to the Hrd1/Htm1 endoplasmic reticulum-associated degradation system

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912342

The role of CDC48 in the retro-translocation of non-ubiquitinated toxin substrates in plant cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912342

The recognition and retrotranslocation of misfolded proteins from the endoplasmic reticulum

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912342

To be, or not to be--molecular chaperones in protein degradation

27 September 2017

1 reference

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Retrotranslocation of a viral A/B toxin from the yeast endoplasmic reticulum is independent of ubiquitination and ERAD.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912342

Entry of protein toxins into mammalian cells by crossing the endoplasmic reticulum membrane: co-opting basic mechanisms of endoplasmic reticulum-associated degradation

27 September 2017

1 reference

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The role of p97/Cdc48p in endoplasmic reticulum-associated degradation: from the immune system to yeast.

27 September 2017

1 reference

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The Png1-Rad23 complex regulates glycoprotein turnover

27 September 2017

1 reference

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Single, context-specific glycans can target misfolded glycoproteins for ER-associated degradation

27 September 2017

1 reference

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Reductive activation of ricin and ricin A-chain immunotoxins by protein disulfide isomerase and thioredoxin reductase

27 September 2017

1 reference

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Distinct steps in dislocation of luminal endoplasmic reticulum-associated degradation substrates: roles of endoplamic reticulum-bound p97/Cdc48p and proteasome

27 September 2017

1 reference

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ER-to-Golgi transport: COP I and COP II function (Review).

27 September 2017

1 reference

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Role of ubiquitination in retro-translocation of cholera toxin and escape of cytosolic degradation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912342

Protein dislocation from the endoplasmic reticulum--pulling out the suspect

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912342

The low lysine content of ricin A chain reduces the risk of proteolytic degradation after translocation from the endoplasmic reticulum to the cytosol

27 September 2017

1 reference

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The p24 proteins are not essential for vesicular transport in Saccharomyces cerevisiae

27 September 2017

1 reference

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Export of a cysteine-free misfolded secretory protein from the endoplasmic reticulum for degradation requires interaction with protein disulfide isomerase

27 September 2017

1 reference

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Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway

27 September 2017

1 reference

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Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912342

Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway

27 September 2017

1 reference

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Accumulating evidence suggests that several AB-toxins subvert the endoplasmic reticulum-associated protein degradation pathway to enter target cells

30 May 2018

1 reference

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The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.

30 May 2018

1 reference

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Structure of a ricin mutant showing rescue of activity by a noncatalytic residue

30 May 2018

1 reference

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Endoplasmic reticulum-associated degradation of ricin A chain has unique and plant-specific features.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912342

Isolation and characterization of an RIP (ribosome-inactivating protein)-like protein from tobacco with dual enzymatic activity

28 November 2018

1 reference

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Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912342

Ribosome-mediated folding of partially unfolded ricin A-chain.

28 November 2018

1 reference

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Mutagenesis and kinetic analysis of the active site Glu177 of ricin A-chain.

28 November 2018

1 reference

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Intracellular folding of tissue-type plasminogen activator. Effects of disulfide bond formation on N-linked glycosylation and secretion

28 November 2018

1 reference

12 December 2020

Point mutations in the hydrophobic C-terminal region of ricin A chain indicate that Pro250 plays a key role in membrane translocation

1 reference

12 December 2020

A RING-H2 finger motif is essential for the function of Der3/Hrd1 in endoplasmic reticulum associated protein degradation in the yeast Saccharomyces cerevisiae

1 reference

12 December 2020

Ricin A chain utilises the endoplasmic reticulum-associated protein degradation pathway to enter the cytosol of yeast

1 reference

12 December 2020

SnapShot: ER-associated protein degradation pathways

1 reference

12 December 2020

Dependence of ricin toxicity on translocation of the toxin A-chain from the endoplasmic reticulum to the cytosol

1 reference

12 December 2020

Degradation of endoplasmic reticulum (ER) quality control substrates requires transport between the ER and Golgi

1 reference

12 December 2020

Brefeldin A causes a defect in secretion in Saccharomyces cerevisiae

1 reference

12 December 2020

Identifiers

DOI

10.1091/MBC.E09-08-0743

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20519439%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20519439%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

PubMed publication ID

20519439

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20519439%20AND%20SRC:MED&resulttype=core&format=json