Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments (Q24599152)

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M Novak

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I Grundke-Iqbal

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K Iqbal

Proceedings of the National Academy of Sciences of the United States of America

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language of work or name

English

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publication date

5 June 2001

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published in

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volume

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issue

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page(s)

6923-8

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cites work

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Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

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Hyperphosphorylation of tau in PHF

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Structure of tau protein and assembly into paired helical filaments

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Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

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Alzheimer neurofibrillary tangles contain 2.1 nm filaments structurally identical to the microtubule-associated protein τ: a high-resolution transmission electron microscope study of tangles and senile plaque core amyloid

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Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains

27 September 2017

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Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro

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30 May 2018

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30 May 2018

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30 May 2018

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Microtubule-associated protein tau. A component of Alzheimer paired helical filaments

30 May 2018

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Defective brain microtubule assembly in Alzheimer's disease

30 May 2018

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A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

30 May 2018

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Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein

30 May 2018

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Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms

30 May 2018

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The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease

30 May 2018

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In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification.

30 May 2018

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Protein anatomy: C-tail region of human tau protein as a crucial structural element in Alzheimer's paired helical filament formation in vitro

28 November 2018

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Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

28 November 2018

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Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer's disease

28 November 2018

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Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.

28 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=34454

The organization of the microtubule associated protein tau in Alzheimer paired helical filaments

28 November 2018

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Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.

28 November 2018

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Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B.

28 November 2018

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The microtubule-associated protein tau forms a triple-stranded left-hand helical polymer

28 November 2018

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12 December 2020

Polymerization of Microtubule-associated Protein Tau under Near-physiological Conditions

1 reference

12 December 2020

Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction

1 reference

12 December 2020

Phosphorylated, but not native, tau protein assembles following reaction with the lipid peroxidation product, 4-hydroxy-2-nonenal

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12 December 2020

Assay of proteins in the presence of interfering materials

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12 December 2020

Self assembly of microtubule associated protein tau into filaments resembling those found in Alzheimer disease

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12 December 2020

Polymerization of tau peptides into fibrillar structures. The effect of FTDP-17 mutations

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12 December 2020

Assembly of paired helical filaments from mouse tau: implications for the neurofibrillary pathology in transgenic mouse models for Alzheimer's disease

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12 December 2020

Identifiers

DOI

10.1073/PNAS.121119298

1 reference

ADS bibcode

2001PNAS...98.6923A

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1 reference

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PubMed publication ID

11381127

1 reference