Loop 5-directed compounds inhibit chimeric kinesin-5 motors: implications for conserved allosteric mechanisms (Q24598085)

28 October 2024

Sreeja Parameswaran

Sreeja

Parameswaran

1 reference

28 October 2024

Jing Liu

Jing

Liu

1 reference

28 October 2024

Sunyoung Kim

Sunyoung

Kim

1 reference

28 October 2024

Edward J Wojcik

Edward J

Wojcik

1 reference

Journal of Biological Chemistry

28 October 2024

language of work or name

English

0 references

publication date

25 February 2011

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published in

0 references

volume

286

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issue

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page(s)

6201-10

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cites work

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol

27 September 2017

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Understanding noncovalent interactions: ligand binding energy and catalytic efficiency from ligand-induced reductions in motion within receptors and enzymes

27 September 2017

1 reference

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Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5.

27 September 2017

1 reference

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27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057856

Disparity in allosteric interactions of monastrol with Eg5 in the presence of ADP and ATP: a difference FT-IR investigation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057856

Entropy-enthalpy compensation: fact or artifact?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057856

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27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057856

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30 May 2018

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Crystal structure of HsEg5 in complex with clinical candidate CK0238273 provides insight into inhibitory mechanism, potency, and specificity

30 May 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

Characterization of inhibitor binding to human kinesin spindle protein by site-directed mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

Monastrol stabilises an attached low-friction mode of Eg5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

Ca2+/calmodulin regulation of the Arabidopsis kinesin-like calmodulin-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

Interaction of the mitotic inhibitor monastrol with human kinesin Eg5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

Molecular dynamics simulation study of PTP1B with allosteric inhibitor and its application in receptor based pharmacophore modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

Mechanism of inhibition of human KSP by ispinesib

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

The effect of monastrol on the processive motility of a dimeric kinesin-5 head/kinesin-1 stalk chimera

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

Mechanism of inhibition of human KSP by monastrol: insights from kinetic analysis and the effect of ionic strength on KSP inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

Isothermal titration calorimetry reveals differential binding thermodynamics of variable region-identical antibodies differing in constant region for a univalent ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.154989

Novel benzimidazole inhibitors bind to a unique site in the kinesin spindle protein motor domain

21 January 2018

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A pathway of structural changes produced by monastrol binding to Eg5.

21 January 2018

1 reference

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Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/21127071

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Heat does not come in different colours: entropy-enthalpy compensation, free energy windows, quantum confinement, pressure perturbation calorimetry, solvation and the multiple causes of heat capacity effects in biomolecular interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/21127071

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.154989

0 references

Fatcat ID

release_f5qv6txstfhzbiljyxgycnub6e

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PMC publication ID

3057856

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