A Grb2-associated docking protein in EGF- and insulin-receptor signalling (Q24321653)

insulin receptor signaling pathway

GOA release 2020-03-11

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GOA release 2020-03-11

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M Holgado-Madruga

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D R Emlet

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D K Moscatello

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A K Godwin

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A J Wong

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

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language of work or name

English

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publication date

8 February 1996

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published in

Nature

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volume

379

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issue

6565

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page(s)

560-4

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cites work

1 reference

7 January 2021

The GRB2/Sem-5 adaptor protein

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7 January 2021

Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites

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7 January 2021

Binding of Vav to Grb2 through dimerization of Src homology 3 domains

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7 January 2021

The GTPase dynamin binds to and is activated by a subset of SH3 domains

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7 January 2021

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

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7 January 2021

Human Skeletal Muscle Insulin Receptor Substrate-1: Characterization of the cDNA, Gene, and Chromosomal Localization

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7 January 2021

The PH domain: a common piece in the structural patchwork of signalling proteins

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7 January 2021

The function of GRB2 in linking the insulin receptor to Ras signaling pathways

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7 January 2021

Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells

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7 January 2021

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

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7 January 2021

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

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7 January 2021

SH2 domains recognize specific phosphopeptide sequences

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7 January 2021

Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain

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7 January 2021

Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase

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7 January 2021

The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains

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7 January 2021

ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor

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7 January 2021

Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes

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7 January 2021

Association between GRB2/Sos and insulin receptor substrate 1 is not sufficient for activation of extracellular signal-regulated kinases by interleukin-4: implications for Ras activation by insulin

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7 January 2021

Insulin Receptor Substrate 1 Rescues Insulin Action in CHO Cells Expressing Mutant Insulin Receptors That Lack a Juxtamembrane NPXY Motif

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7 January 2021

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

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7 January 2021

Association of insulin receptor substrate-1 with integrins

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7 January 2021

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

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7 January 2021

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

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7 January 2021

Role of IRS-2 in insulin and cytokine signalling

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7 January 2021

Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions

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7 January 2021