Mexiletine differentially restores the trafficking defects caused by two brugada syndrome mutations (Q24317193)

membrane depolarization during action potential

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

0 references

Adrien Moreau

0 references

Dagmar I Keller

0 references

Hai Huang

0 references

Christian Schmied

0 references

Quadiri Timour

0 references

Mohamed Chahine

Frontiers in Pharmacology

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language of work or name

English

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publication date

2012

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published in

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volume

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page(s)

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cites work

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Sodium channel β1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans

19 March 2017

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Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias

19 March 2017

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Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. Pharmacological and temperature effects

19 March 2017

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A review of the mechanisms of ventricular arrhythmia in brugada syndrome

19 March 2017

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27 September 2017

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Neurally mediated syncope as a cause of syncope in patients with Brugada electrocardiogram

27 September 2017

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Hyperthermia in the febrile range induces HSP72 expression proportional to exposure temperature but not to HSF-1 DNA-binding activity in human lung epithelial A549 cells

27 September 2017

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SCN5A channelopathies--an update on mutations and mechanisms

27 September 2017

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A novel SCN5A mutation, F1344S, identified in a patient with Brugada syndrome and fever-induced ventricular fibrillation

27 September 2017

1 reference

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Brugada syndrome and fever: genetic and molecular characterization of patients carrying SCN5A mutations.

27 September 2017

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Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects

27 September 2017

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A trafficking defective, Brugada syndrome-causing SCN5A mutation rescued by drugs

27 September 2017

1 reference

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Proposed diagnostic criteria for the Brugada syndrome: consensus report

27 September 2017

1 reference

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Expression and intracellular localization of an SCN5A double mutant R1232W/T1620M implicated in Brugada syndrome

27 September 2017

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Electrophysiological characterization of SCN5A mutations causing long QT (E1784K) and Brugada (R1512W and R1432G) syndromes

27 September 2017

1 reference

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Y1767C, a novel SCN5A mutation, induces a persistent Na+ current and potentiates ranolazine inhibition of Nav1.5 channels

27 September 2017

1 reference

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Calcium-pump inhibitors induce functional surface expression of Delta F508-CFTR protein in cystic fibrosis epithelial cells

30 May 2018

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Novel mechanism for Brugada syndrome: defective surface localization of an SCN5A mutant (R1432G).

29 November 2018

1 reference

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Differential interaction of R-mexiletine with the local anesthetic receptor site on brain and heart sodium channel alpha-subunits.

29 November 2018

1 reference

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29 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/22529811

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Functional expression of GFP-linked human heart sodium channel (hH1) and subcellular localization of the a subunit in HEK293 cells and dog cardiac myocytes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22529811

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Genomic organization of the human SCN5A gene encoding the cardiac sodium channel

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22529811