Acetylation is indispensable for p53 activation (Q24313477)

GOA release 2020-03-11

author name string

Yi Tang

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Wenhui Zhao

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Yue Chen

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Yingming Zhao

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Wei Gu

Negative regulation of the deacetylase SIRT1 by DBC1

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language of work or name

English

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publication date

16 May 2008

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published in

Cell

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volume

133

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issue

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page(s)

612-26

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cites work

1 reference

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DBC1 is a negative regulator of SIRT1

19 March 2017

1 reference

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An acetylation switch in p53 mediates holo-TFIID recruitment

19 March 2017

1 reference

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hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes

19 March 2017

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Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation

19 March 2017

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19 March 2017

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A large-scale RNAi screen in human cells identifies new components of the p53 pathway

19 March 2017

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Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure

19 March 2017

1 reference

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

19 March 2017

1 reference

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Negative control of p53 by Sir2alpha promotes cell survival under stress

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Regulation of p53 function and stability by phosphorylation

19 March 2017

1 reference

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Translating the Histone Code

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Chromatin immunoprecipitation for determining the association of proteins with specific genomic sequences in vivo

19 March 2017

2 references

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19 March 2017

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The complex language of chromatin regulation during transcription

7 April 2017

1 reference

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Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53

19 March 2017

1 reference

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The ubiquitin ligase COP1 is a critical negative regulator of p53

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Deacetylation of p53 modulates its effect on cell growth and apoptosis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

19 March 2017

Surfing the p53 network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

WAF1, a potential mediator of p53 tumor suppression

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

p53 in health and disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

p53 ubiquitination: Mdm2 and beyond

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

ASPP: a new family of oncogenes and tumour suppressor genes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

MDM2 inhibitors for cancer therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Binding of p53 to the central domain of Mdm2 is regulated by phosphorylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

The central region of HDM2 provides a second binding site for p53.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Mdmx as an essential regulator of p53 activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

The p53-Mdm2 module and the ubiquitin system.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Mutation of mouse p53 Ser23 and the response to DNA damage

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Stress signals utilize multiple pathways to stabilize p53

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Acetylation of the p53 DNA-binding domain regulates apoptosis induction

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Mutational analysis of the p53 core domain L1 loop.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2914560

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18485870

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2008.03.025

1 reference

1 reference

1 reference

PubMed publication ID

18485870

1 reference