14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation (Q24306380)

0 references

Steven Z Lu

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Yingda Xu

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Zhijun Luo

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Yingming Zhao

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Hua Lu

DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation

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language of work or name

English

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publication date

22 March 2006

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1207-18

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cites work

1 reference

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The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

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19 March 2017

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19 March 2017

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

19 March 2017

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Mdm2 promotes the rapid degradation of p53

19 March 2017

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MDMX: a novel p53-binding protein with some functional properties of MDM2

19 March 2017

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Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

19 March 2017

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

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Surfing the p53 network

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Regulation of p53 stability by Mdm2

6 April 2017

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19 March 2017

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MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation

19 March 2017

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Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

19 March 2017

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Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

19 March 2017

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The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1

19 March 2017

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The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

19 March 2017

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14-3-3sigma is a p53-regulated inhibitor of G2/M progression

19 March 2017

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

19 March 2017

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The p53-mdm-2 autoregulatory feedback loop

19 March 2017

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Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

19 March 2017

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A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells

22 April 2017

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

22 April 2017

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The structural basis for 14-3-3:phosphopeptide binding specificity

7 April 2017

1 reference

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Post-translational modifications and activation of p53 by genotoxic stresses

7 April 2017

1 reference

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mdm2 expression is induced by wild type p53 activity

7 April 2017

1 reference

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

7 April 2017

1 reference

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

7 April 2017

1 reference

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ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1422168

Mdmx as an essential regulator of p53 activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1422168

The crystal structure of the non-liganded 14-3-3sigma protein: insights into determinants of isoform specific ligand binding and dimerization

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1422168

Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1422168

A structural basis for 14-3-3sigma functional specificity.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1422168

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1422168

MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1422168

14-3-3σ Positively Regulates p53 and Suppresses Tumor Growth

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1422168

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1422168

Overexpression of Mdm2 and MdmX fusion proteins alters p53 mediated transactivation, ubiquitination, and degradation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1422168

Activation of the p53 tumor suppressor protein

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1422168

Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1422168

Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1422168

MdmX protects p53 from Mdm2-mediated degradation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1422168

A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1422168

Raf-1 kinase and exoenzyme S interact with 14-3-3zeta through a common site involving lysine 49.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1422168

p300 does not require its acetylase activity to stimulate p73 function

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1422168

Structure and organization of amplified DNA on double minutes containing the mdm2 oncogene

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1422168

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

30 May 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601010

Phosphorylation of MdmX by CDK2/Cdc2(p34) is required for nuclear export of Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601010

C2 Region-derived Peptides Inhibit Translocation and Function of β Protein Kinase C in Vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601010

A novel form of Epstein-Barr virus latency in normal B cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601010

Identification of a domain within MDMX-S that is responsible for its high affinity interaction with p53 and high-level expression in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601010

Identification of the 14.3.3 zeta domains important for self-association and Raf binding

21 January 2018

1 reference

12 December 2020

The p38MAPK inhibitor SB203580 alleviates ultraviolet-induced phosphorylation at serine 389 but not serine 15 and activation of p53

1 reference

12 December 2020

Hdmx stabilizes Mdm2 and p53

1 reference

12 December 2020

UV but not gamma irradiation accelerates p53-induced apoptosis of teratocarcinoma cells by repressing MDM2 transcription

1 reference

12 December 2020

mdmx is a negative regulator of p53 activity in vivo

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.EMBOJ.7601010

1 reference

1 reference

1 reference

PubMed publication ID

16511572

1 reference