Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1 (Q24305550)

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Baomin Li

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Sonia Navarro

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Noriyuki Kasahara

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Lucio Comai

Journal of Biological Chemistry

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language of work or name

English

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publication date

2 April 2004

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published in

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volume

279

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issue

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page(s)

13659-67

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The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

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Functional interaction between the Werner Syndrome protein and DNA polymerase delta

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Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.

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Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A

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Werner syndrome helicase contains a 5'-->3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding

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WRN helicase expression in Werner syndrome cell lines

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p53 Modulates the exonuclease activity of Werner syndrome protein

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Functional and physical interaction between WRN helicase and human replication protein A

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Physical and functional interaction between p53 and the Werner's syndrome protein

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The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.

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p53-mediated apoptosis is attenuated in Werner syndrome cells

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WRN interacts physically and functionally with the recombination mediator protein RAD52

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Functional interaction between Ku and the werner syndrome protein in DNA end processing

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DNA double strand break repair in mammalian cells

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Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex

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A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA

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Deletion of Ku86 causes early onset of senescence in mice

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The Werner syndrome protein is a DNA helicase

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Poly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences

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Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase

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Binding of adenosine diphosphoribosyltransferase to the termini and internal regions of linear DNAs

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Central Role for the Werner Syndrome Protein/Poly(ADP-Ribose) Polymerase 1 Complex in the Poly(ADP-Ribosyl)ation Pathway after DNA Damage

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Physical and functional interaction of the Werner syndrome protein with poly‐ADP ribosyl transferase

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Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice

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Poly(ADP-ribosylation) of histones in intact human keratinocytes

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Impaired nuclear localization of defective DNA helicases in Werner's syndrome

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Pathways defective in the human premature aging disease Werner syndrome

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Spontaneous and induced chromosomal instability in Werner syndrome

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Variations in ADP-ribosylation of nuclear scaffold proteins during the HeLa cell cycle

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