Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking (Q24300438)

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

John Q Trojanowski

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author name string

Todd J Cohen

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Andrew W Hwang

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Travis Unger

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Virginia M Y Lee

Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis

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language of work or name

English

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publication date

7 March 2012

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1241-52

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cites work

1 reference

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Structural insights into TDP-43 in nucleic-acid binding and domain interactions

19 March 2017

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TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing

19 March 2017

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Higher order arrangement of the eukaryotic nuclear bodies

19 March 2017

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HDAC6 is a microtubule-associated deacetylase

19 March 2017

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Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping

19 March 2017

1 reference

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The x-ray crystal structure of the first RNA recognition motif and site-directed mutagenesis suggest a possible HuR redox sensing mechanism

19 March 2017

1 reference

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Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

19 March 2017

1 reference

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Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes

19 March 2017

1 reference

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Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue

19 March 2017

1 reference

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TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor

19 March 2017

1 reference

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Metals, toxicity and oxidative stress

19 March 2017

1 reference

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Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9

19 March 2017

1 reference

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RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules

19 March 2017

1 reference

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Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.

7 April 2017

1 reference

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Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.

27 September 2017

1 reference

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TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1.

27 September 2017

1 reference

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Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

TDP-43 regulates its mRNA levels through a negative feedback loop

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

Metals, oxidative stress and neurodegenerative disorders

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.

27 September 2017

1 reference

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Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

27 September 2017

1 reference

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Zinc induces depletion and aggregation of endogenous TDP-43.

27 September 2017

1 reference

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TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-Delta(12,14)-prostaglandin J(2).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

Redox homeostasis and cellular stress response in aging and neurodegeneration

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

TDP-43 is recruited to stress granules in conditions of oxidative insult.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

Rethinking ALS: the FUS about TDP-43.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

Cysteine oxidation regulates the RNA-binding activity of iron regulatory protein 2

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

Structural determinants of the cellular localization and shuttling of TDP-43.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

Inactivation of the SMN complex by oxidative stress

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

A limited role for disulfide cross-linking in the aggregation of mutant SOD1 linked to familial amyotrophic lateral sclerosis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

Relevance of oxidative injury in the pathogenesis of motor neuron diseases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

Familial amyotrophic lateral sclerosis mutants of copper/zinc superoxide dismutase are susceptible to disulfide reduction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3297986

Human, Drosophila, and C.elegans TDP43: nucleic acid binding properties and splicing regulatory function

27 September 2017

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.471

Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.471

21 January 2018

Identifiers

DOI

10.1038/EMBOJ.2011.471

1 reference

1 reference

1 reference

PubMed publication ID

22193716

1 reference