Daxx is reciprocally regulated by Mdm2 and Hausp (Q24299167)

GOA release 2020-03-11

author name string

Jun Tang

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Like Qu

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Mingsu Pang

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Xiaolu Yang

Biochemical and Biophysical Research Communications

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language of work or name

English

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publication date

12 March 2010

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published in

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volume

393

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issue

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page(s)

542-5

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cites work

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Daxx Silencing Sensitizes Cells to Multiple Apoptotic Pathways

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The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies

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Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity

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Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek

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TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation

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EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes

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Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development

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Phosphorylation-dependent Lys63-linked polyubiquitination of Daxx is essential for sustained TNF-{alpha}-induced ASK1 activation

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Daxx is a transcriptional repressor of CCAAT/enhancer-binding protein beta

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Stress-dependent Daxx-CHIP interaction suppresses the p53 apoptotic program

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Mdm2 affects genome stability independent of p53.

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Human cytomegalovirus protein pp71 displaces the chromatin-associated factor ATRX from nuclear domain 10 at early stages of infection

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Proteasome-dependent, ubiquitin-independent degradation of Daxx by the viral pp71 protein in human cytomegalovirus-infected cells

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MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation

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Human cytomegalovirus (HCMV) UL82 gene product (pp71) relieves hDaxx-mediated repression of HCMV replication

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Mdm2-mediated pRB downregulation is involved in carcinogenesis in a p53-independent manner

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Tryptophan 621 and serine 667 residues of Daxx regulate its nuclear export during glucose deprivation.

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Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs).

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A suppressive role of the prolyl isomerase Pin1 in cellular apoptosis mediated by the death-associated protein Daxx

27 September 2017

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BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.

29 November 2018

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Daxx is required for stress-induced cell death and JNK activation.

29 November 2018

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Chemosensitization and radiosensitization of human cancer by antisense anti-MDM2 oligonucleotides: in vitro and in vivo activities and mechanisms

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Oncoprotein MDM2 overexpression is associated with poor prognosis in distinct non-Hodgkin's lymphoma entities

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