Mechanism for down-regulation of CD28 by Nef. (Q24291079)

6 July 2017

title

Mechanism for down-regulation of CD28 by Nef. (English)

1 reference

6 July 2017

T Swigut

0 references

N Shohdy

1 reference

6 July 2017

J Skowronski

series ordinal

1 reference

6 July 2017

language of work or name

English

0 references

publication date

1 April 2001

1 reference

6 July 2017

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6 July 2017

1 reference

6 July 2017

1 reference

6 July 2017

page(s)

1593-1604

1 reference

HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

6 July 2017

cites work

1 reference

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Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity

19 March 2017

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Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes

19 March 2017

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Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation

19 March 2017

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Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

19 March 2017

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19 March 2017

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Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail

19 March 2017

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19 March 2017

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The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells

19 March 2017

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A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4

19 March 2017

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A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor

19 March 2017

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19 March 2017

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Importance of the nef gene for maintenance of high virus loads and for development of AIDS

7 April 2017

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HIV and SIV Nef modulate signal transduction and protein sorting in T cells

7 April 2017

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Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo

27 September 2017

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Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation.

27 September 2017

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Simian and human immunodeficiency virus Nef proteins use different surfaces to downregulate class I major histocompatibility complex antigen expression

27 September 2017

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T cells can use either T cell receptor or CD28 receptors to absorb and internalize cell surface molecules derived from antigen-presenting cells

27 September 2017

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Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway

27 September 2017

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Interactions of HIV-1 NEF with cellular signal transducing proteins

27 September 2017

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Adaptors for clathrin-mediated traffic

27 September 2017

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The human immunodeficiency virus type 1 nef gene can to a large extent replace simian immunodeficiency virus nef in vivo.

27 September 2017

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HIV's evasion of the cellular immune response

27 September 2017

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The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors

27 September 2017

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HIV-1 Nef increases T cell activation in a stimulus-dependent manner

27 September 2017

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Induction of AIDS in rhesus monkeys by a recombinant simian immunodeficiency virus expressing nef of human immunodeficiency virus type 1.

27 September 2017

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Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis

27 September 2017

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Zeta chain of the T-cell receptor interacts with nef of simian immunodeficiency virus and human immunodeficiency virus type 2

27 September 2017

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Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules

27 September 2017

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The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes

27 September 2017

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Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus Nef use distinct but overlapping target sites for downregulation of cell surface CD4.

27 September 2017

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A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 nef alleles in lymphocyte activation.

27 September 2017

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CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1.

27 September 2017

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The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR.

27 September 2017

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Endocytic and exocytic regulation of CD4 expression and function

27 September 2017

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CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals

27 September 2017

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Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene

27 September 2017

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Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes

27 September 2017

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Structural relationships between clathrin assembly proteins from the Golgi and the plasma membrane

27 September 2017

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Roles of adhesion molecules in T-cell recognition: fundamental similarities between four integrins on resting human T cells (LFA-1, VLA-4, VLA-5, VLA-6) in expression, binding, and costimulation

27 September 2017

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Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA.

27 September 2017

1 reference

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Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

27 September 2017

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27 September 2017

Nef--an adaptor adaptor?

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30 May 2018

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CD28 receptor endocytosis is targeted by mutations that disrupt phosphatidylinositol 3-kinase binding and costimulation.

30 May 2018

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The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.

30 May 2018

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Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2

30 May 2018

1 reference

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Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) zeta chain leads to TCR down-modulation

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=145469

HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

29 November 2018

1 reference

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Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11285224

12 December 2020

inferred from PubMed ID database lookup

HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11285224

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1093/EMBOJ/20.7.1593

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ueikqmruavaihpbe4brysxcjsm

30 July 2022

release_ueikqmruavaihpbe4brysxcjsm

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/ueikqmruavaihpbe4brysxcjsm

30 July 2022

https://api.fatcat.wiki/v0/release/ueikqmruavaihpbe4brysxcjsm

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30 July 2022

https://api.fatcat.wiki/v0/release/ueikqmruavaihpbe4brysxcjsm

1 reference

30 July 2022