VPS35 retromer complex component (Q21992727)

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mammalian protein found in Mus musculus

maternal-embryonic 3
vacuolar protein sorting 35
vacuolar protein sorting-associated protein 35
vesicle protein sorting 35
maternal embryonic message 3
Vps35

Language	Label	Description	Also known as
English	VPS35 retromer complex component	mammalian protein found in Mus musculus	maternal-embryonic 3 vacuolar protein sorting 35 vacuolar protein sorting-associated protein 35 vesicle protein sorting 35 maternal embryonic message 3 Vps35

Statements

1 reference

25 May 2022

UniProt protein ID

Vacuolar protein sorting-associated protein 35

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9EQH3

Armadillo-type fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9EQH3

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

protein binding

determination method or standard

11 references

14 February 2019

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

VPS35 regulates cell surface recycling and signaling of dopamine receptor D1

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

Identification of novel retromer complexes in the mouse testis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

Snx3 regulates recycling of the transferrin receptor and iron assimilation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

Deficits in receptor-mediated endocytosis and recycling in cells from mice with Gpr107 locus disruption

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

Implication of mouse Vps26b–Vps29–Vps35 retromer complex in sortilin trafficking

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

D1 dopamine receptor binding

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

VPS35 regulates cell surface recycling and signaling of dopamine receptor D1

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

integral component of membrane

determination method or standard

1 reference

14 February 2019

Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

tubular endosome

determination method or standard

retromer complex

determination method or standard

3 references

31 January 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9EQH3&geneProductId=UniProtKB:Q9EQH3

determination method or standard

31 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9EQH3&geneProductId=UniProtKB:Q9EQH3

determination method or standard

31 January 2018

Implication of mouse Vps26b–Vps29–Vps35 retromer complex in sortilin trafficking

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9EQH3&geneProductId=UniProtKB:Q9EQH3

determination method or standard

determination method or standard

postsynaptic density

determination method or standard

1 reference

14 February 2019

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

retromer, cargo-selective complex

determination method or standard

determination method or standard

3 references

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

neuron projection

determination method or standard

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

determination method or standard

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

perinuclear region of cytoplasm

determination method or standard

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

determination method or standard

5 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

plasma membrane

determination method or standard

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

retromer complex

determination method or standard

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

Implication of mouse Vps26b–Vps29–Vps35 retromer complex in sortilin trafficking

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

determination method or standard

1 reference

14 February 2019

VPS35 depletion does not impair presynaptic structure and function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

glutamatergic synapse

determination method or standard

5 references

14 February 2019

VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

The Retromer Supports AMPA Receptor Trafficking During LTP.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

The Retromer Supports AMPA Receptor Trafficking During LTP.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

biological process

positive regulation of Wnt protein secretion

determination method or standard

1 reference

14 February 2019

The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

positive regulation of canonical Wnt signaling pathway

determination method or standard

1 reference

14 February 2019

The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

vacuolar protein processing

determination method or standard

1 reference

14 February 2019

Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

determination method or standard

neurotransmitter receptor transport, endosome to plasma membrane

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

VPS35 regulates cell surface recycling and signaling of dopamine receptor D1

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

lysosome organization

determination method or standard

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

positive regulation of gene expression

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

negative regulation of gene expression

determination method or standard

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

protein destabilization

determination method or standard

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

negative regulation of protein homooligomerization

determination method or standard

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

protein localization to organelle

determination method or standard

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

voluntary musculoskeletal movement

determination method or standard

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

positive regulation of locomotion involved in locomotory behavior

determination method or standard

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

positive regulation of dopamine biosynthetic process

determination method or standard

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

negative regulation of protein localization

determination method or standard

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

negative regulation of lysosomal protein catabolic process

determination method or standard

1 reference

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

retrograde transport, endosome to Golgi

determination method or standard

6 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

negative regulation of neuron death

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

intracellular protein transport

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

synapse assembly

determination method or standard

3 references

14 February 2019

VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

14 February 2019

VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQH3

determination method or standard

protein localization to endosome

determination method or standard

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000034131

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000034131

Sitelinks

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Multilingual sites(0 entries)

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