Low density lipoprotein receptor-related protein 2 (Q21981311)

Six-bladed beta-propeller, TolB-like

1 reference

Growth factor receptor cysteine-rich domain superfamily

1 reference

Putative uncharacterized transport proteins

1 reference

Transporter Classification Database ID

9.B.87.1.1

retrieved

2 October 2019

hierarchical database ID heuristic

EGF-like calcium-binding domain, protein family

1 reference

EGF-like domain, protein family

1 reference

Low-density lipoprotein (LDL) receptor class A, conserved site, protein family

1 reference

EGF-like, conserved site, protein family

1 reference

Low-density lipoprotein (LDL) receptor class A repeat, protein family

1 reference

Complement Clr-like EGF domain, protein family

1 reference

LDLR class B repeat, protein family

1 reference

EGF-like calcium-binding, conserved site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 references

8 April 2019

LRP2/megalin is required for patterning of the ventral telencephalon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

Megalin interacts with APP and the intracellular adapter protein FE65 in neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

Megalin is a receptor for apolipoprotein M, and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein M.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

cargo receptor activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=A2ARV4&geneProductId=UniProtKB:A2ARV4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

protein-containing complex binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

low-density lipoprotein particle receptor binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=A2ARV4&geneProductId=UniProtKB:A2ARV4

integral component of membrane

IEA

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

8 April 2019

Expression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

8 April 2019

Expression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

3 references

8 April 2019

Expression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

Arf4 is required for Mammalian development but dispensable for ciliary assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

Expression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryo

endoplasmic reticulum

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

apical plasma membrane

6 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

Expression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

brush border membrane

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

protein-containing complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=A2ARV4&geneProductId=UniProtKB:A2ARV4

ventricular septum development

IEA

1 reference

8 April 2019

Global genetic analysis in mice unveils central role for cilia in congenital heart disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

coronary vasculature development

1 reference

8 April 2019

Global genetic analysis in mice unveils central role for cilia in congenital heart disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

8 April 2019

Global genetic analysis in mice unveils central role for cilia in congenital heart disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

8 April 2019

Global genetic analysis in mice unveils central role for cilia in congenital heart disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

vitamin metabolic process

1 reference

8 April 2019

An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

LRP2/megalin is required for patterning of the ventral telencephalon

forebrain development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

cell population proliferation

1 reference

8 April 2019

LRP2/megalin is required for patterning of the ventral telencephalon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

8 April 2019

LRP2 mediates folate uptake in the developing neural tube

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

secondary heart field specification

1 reference

8 April 2019

Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

outflow tract septum morphogenesis

1 reference

8 April 2019

Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

ventricular compact myocardium morphogenesis

1 reference

8 April 2019

Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

Role of endocytosis in cellular uptake of sex steroids.

male gonad development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

negative regulation of BMP signaling pathway

1 reference

8 April 2019

LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

positive regulation of neurogenesis

1 reference

8 April 2019

LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

8 April 2019

Role of endocytosis in cellular uptake of sex steroids.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

coronary artery morphogenesis

1 reference

8 April 2019

Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

pulmonary artery morphogenesis

1 reference

8 April 2019

Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

positive regulation of oligodendrocyte progenitor proliferation

1 reference

8 April 2019

Megalin mediates the influence of sonic hedgehog on oligodendrocyte precursor cell migration and proliferation during development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

neuron projection arborization

1 reference

8 April 2019

Megalin interacts with APP and the intracellular adapter protein FE65 in neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

folate import across plasma membrane

1 reference

8 April 2019

LRP2 mediates folate uptake in the developing neural tube

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

receptor-mediated endocytosis

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

Megalin-mediated endocytosis of cystatin C in proximal tubule cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

8 April 2019

LRP2/megalin is required for patterning of the ventral telencephalon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

nervous system development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

endocytic hemoglobin import into cell

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

lipoprotein transport

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=A2ARV4&geneProductId=UniProtKB:A2ARV4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

positive regulation of endocytosis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

positive regulation of lipoprotein transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

chemoattraction of axon

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A2ARV4

EGF-like calcium-binding, conserved site

has part(s)

1 reference

EGF-like calcium-binding domain

1 reference

low-density lipoprotein (LDL) receptor class A repeat

1 reference

LDLR class B repeat

1 reference

EGF-like, conserved site

1 reference

Complement Clr-like EGF domain

1 reference

EGF-type aspartate/asparagine hydroxylation site

1 reference

EGF-like domain

1 reference

Low-density lipoprotein (LDL) receptor class A, conserved site

1 reference

Transporter Classification Database ID

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

9.B.87.1.1

1 reference