Tumor suppressor ARF (Q21499012)

http://www.ebi.ac.uk/interpro/protein/Q64364

1 reference

10 August 2016

1 reference

10 August 2016

English

molecular function

DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

1 reference

14 February 2019

protein N-terminus binding

1 reference

14 February 2019

Structural polymorphism in the N-terminal oligomerization domain of NPM1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

DNA-binding transcription factor activity

1 reference

14 February 2019

CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

NF-kappaB binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

ubiquitin-protein transferase inhibitor activity

1 reference

14 February 2019

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

protein binding

7 references

14 February 2019

Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

14 February 2019

ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

14 February 2019

Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

14 February 2019

The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

14 February 2019

Bidirectional autoregulatory mechanism of metastasis-associated protein 1-alternative reading frame pathway in oncogenesis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

14 February 2019

The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

14 February 2019

Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

cyclin-dependent protein serine/threonine kinase inhibitor activity

Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

14 February 2019

Cloning and characterization of murine p16INK4a and p15INK4b genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

14 February 2019

Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

protein kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

p53 binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

transcription factor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

SUMO transferase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

disordered domain specific binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

ubiquitin ligase inhibitor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

senescence-associated heterochromatin focus

cell component

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

granular component

1 reference

14 February 2019

CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

nucleoplasm

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

14 February 2019

14 February 2019

CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

nucleolus

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

14 February 2019

14 February 2019

Nucleophosmin is required for DNA integrity and p19Arf protein stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

14 February 2019

The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

14 February 2019

Defining the molecular basis of Arf and Hdm2 interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

14 February 2019

Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

14 February 2019

ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

14 February 2019

Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

14 February 2019

CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

nuclear body

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

regulation of nucleocytoplasmic transport

biological process

1 reference

14 February 2019

ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

regulation of cyclin-dependent protein serine/threonine kinase activity

1 reference

14 February 2019

Cloning and characterization of murine p16INK4a and p15INK4b genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

regulation of protein stability

1 reference

14 February 2019

CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

negative regulation of immature T cell proliferation in thymus

1 reference

14 February 2019

Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

somatic stem cell population maintenance

1 reference

14 February 2019

Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

glucose homeostasis

1 reference

14 February 2019

Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

negative regulation of cyclin-dependent protein serine/threonine kinase activity

2 references

replicative senescence

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

somatic stem cell division

1 reference

14 February 2019

Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

human ageing

1 reference

14 February 2019

The ink4a/arf tumor suppressors cooperate with p21cip1/waf in the processes of mouse epidermal differentiation, senescence, and carcinogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

rRNA transcription

1 reference

14 February 2019

Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

negative regulation of mammary gland epithelial cell proliferation

1 reference

14 February 2019

p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

negative regulation of cell cycle

1 reference

14 February 2019

ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

positive regulation of DNA-binding transcription factor activity

1 reference

14 February 2019

PTEN regulation by Akt-EGR1-ARF-PTEN axis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

negative regulation of protein binding

1 reference

14 February 2019

Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

positive regulation of apoptotic process involved in mammary gland involution

1 reference

14 February 2019

p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64364&geneProductId=UniProtKB:Q64364

1 reference

24 April 2018

negative regulation of cell-matrix adhesion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

cellular senescence

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

14 February 2019

The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

14 February 2019

c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

negative regulation of ubiquitin-protein transferase activity

1 reference

14 February 2019

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

positive regulation of cellular senescence

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

epidermis development

1 reference

14 February 2019

The ink4a/arf tumor suppressors cooperate with p21cip1/waf in the processes of mouse epidermal differentiation, senescence, and carcinogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

rRNA processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

1 reference

14 February 2019

regulation of gene expression

1 reference

14 February 2019

Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

1 reference

14 February 2019

negative regulation of phosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

negative regulation of transcription, DNA-templated

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

negative regulation of B cell proliferation

1 reference

14 February 2019

Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

negative regulation of NF-kappaB transcription factor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

cellular response to hydrogen peroxide

1 reference

14 February 2019

A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

autophagy of mitochondrion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

negative regulation of protein kinase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

activation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

apoptotic mitochondrial changes

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

regulation of G2/M transition of mitotic cell cycle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

protein sumoylation

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

protein destabilization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

positive regulation of protein sumoylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

positive regulation of transcription by RNA polymerase II

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

regulation of protein export from nucleus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

protein stabilization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

mitochondrial depolarization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

positive regulation of protein localization to nucleus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

positive regulation of signal transduction by p53 class mediator

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

regulation of apoptotic DNA fragmentation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

regulation of protein targeting to mitochondrion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

positive regulation of gene expression

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

negative regulation of ubiquitin protein ligase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

amyloid fibril formation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

negative regulation of protein neddylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

G1/S transition of mitotic cell cycle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

response to organonitrogen compound

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

response to organic cyclic compound

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

negative regulation of hepatocyte proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

regulation of transcription, DNA-templated

1 reference

14 February 2019

CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64364

Identifiers

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016