Sine oculis-related homeobox 4 (Q21497911)

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mammalian protein found in Mus musculus

sine oculis-related homeobox 4 homolog
sine oculis homeobox homolog 4
homeobox protein SIX4
Six4
skeletal muscle-specific ARE-binding protein AREC3

Language	Label	Description	Also known as
English	Sine oculis-related homeobox 4	mammalian protein found in Mus musculus	sine oculis-related homeobox 4 homolog sine oculis homeobox homolog 4 homeobox protein SIX4 Six4 skeletal muscle-specific ARE-binding protein AREC3

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Homeobox-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61321

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox protein SIX1, N-terminal SD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

determination method

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

14 February 2019

Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

sequence-specific DNA binding

determination method

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

14 February 2019

Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

14 February 2019

Identification and expression of six family genes in mouse retina

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

14 February 2019

Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

transcription cis-regulatory region binding

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61321&geneProductId=UniProtKB:Q61321

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

determination method

5 references

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61321&geneProductId=UniProtKB:Q61321

determination method

27 March 2018

Localization of Six4/AREC3 in the developing mouse retina; implications in mammalian retinal development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61321&geneProductId=UniProtKB:Q61321

determination method

27 March 2018

Identification and expression of six family genes in mouse retina

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61321&geneProductId=UniProtKB:Q61321

determination method

27 March 2018

Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61321&geneProductId=UniProtKB:Q61321

determination method

27 March 2018

Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61321&geneProductId=UniProtKB:Q61321

determination method

determination method

6 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

14 February 2019

Localization of Six4/AREC3 in the developing mouse retina; implications in mammalian retinal development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

14 February 2019

Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

14 February 2019

Identification and expression of six family genes in mouse retina

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

14 February 2019

Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

transcription regulator complex

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

biological process

negative regulation of neuron apoptotic process

determination method

1 reference

14 February 2019

Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

embryonic skeletal system morphogenesis

determination method

1 reference

14 February 2019

Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

myoblast migration

determination method

1 reference

14 February 2019

Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

positive regulation of branching involved in ureteric bud morphogenesis

determination method

1 reference

14 February 2019

Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

male gonad development

determination method

1 reference

14 February 2019

Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

regulation of transcription, DNA-templated

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

olfactory placode formation

determination method

1 reference

14 February 2019

Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

tongue development

determination method

1 reference

14 February 2019

Development of gustatory papillae in the absence of Six1 and Six4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

anatomical structure development

determination method

1 reference

27 March 2018

Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61321&geneProductId=UniProtKB:Q61321

determination method

thymus development

determination method

1 reference

14 February 2019

Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

myotome development

determination method

trigeminal ganglion development

determination method

1 reference

14 February 2019

Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

negative regulation of apoptotic process

determination method

1 reference

14 February 2019

Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

male sex determination

determination method

1 reference

14 February 2019

Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

skeletal muscle fiber differentiation

determination method

1 reference

14 February 2019

Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

regulation of branch elongation involved in ureteric bud branching

determination method

1 reference

14 February 2019

Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61321&geneProductId=UniProtKB:Q61321

determination method

fungiform papilla morphogenesis

determination method

1 reference

14 February 2019

Development of gustatory papillae in the absence of Six1 and Six4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

generation of neurons

determination method

1 reference

14 February 2019

Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

regulation of protein localization

determination method

1 reference

14 February 2019

Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

multicellular organism development

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

positive regulation of transcription, DNA-templated

determination method

6 references

14 February 2019

Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

14 February 2019

Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

14 February 2019

Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

14 February 2019

Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

14 February 2019

Six1 and Six4 gene expression is necessary to activate the fast-type muscle gene program in the mouse primary myotome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

14 February 2019

Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

inner ear morphogenesis

determination method

1 reference

14 February 2019

Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

male sex differentiation

determination method

1 reference

14 February 2019

Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

positive regulation of ureteric bud formation

determination method

1 reference

14 February 2019

Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

regulation of synaptic assembly at neuromuscular junction

determination method

1 reference

14 February 2019

Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

regulation of gene expression

determination method

1 reference

14 February 2019

Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

protein localization to nucleus

determination method

1 reference

14 February 2019

Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

embryonic cranial skeleton morphogenesis

determination method

1 reference

14 February 2019

Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

negative regulation of satellite cell differentiation

determination method

1 reference

14 February 2019

Six family genes control the proliferation and differentiation of muscle satellite cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

regulation of epithelial cell proliferation

determination method

1 reference

14 February 2019

Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

negative regulation of transcription, DNA-templated

determination method

sarcomere organization

determination method

1 reference

14 February 2019

Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

metanephric mesenchyme development

determination method

1 reference

14 February 2019

Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

14 February 2019

Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

pharyngeal system development

determination method

1 reference

14 February 2019

Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

transcription by RNA polymerase II

determination method

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61321&geneProductId=UniProtKB:Q61321

determination method

negative regulation of transcription, DNA-templated

determination method

3 references

14 February 2019

Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

14 February 2019

Six family genes control the proliferation and differentiation of muscle satellite cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

determination method

Homeobox domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61321

Homeobox, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61321

Homeobox protein SIX1, N-terminal SD domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61321

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000036150

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000036150

ENSMUSP00000135699

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000135699

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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