Wingless-type MMTV integration site family, member 1 (Q21494660)

http://www.ebi.ac.uk/interpro/protein/P04426

Wnt protein, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

protein domain specific binding

1 reference

14 February 2019

Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

10 references

14 February 2019

Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Augmented Wnt signaling in a mammalian model of accelerated aging

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

signaling receptor binding

IPI

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

receptor ligand activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

1 reference

14 February 2019

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

endoplasmic reticulum lumen

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

1 reference

14 February 2019

Properties of Wnt-1 protein that enable cell surface association

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

forebrain anterior/posterior pattern specification

IBA

biological process

1 reference

14 February 2019

Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

dopaminergic neuron differentiation

1 reference

14 February 2019

Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

metencephalon development

1 reference

14 February 2019

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

Insulin and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy

myotube differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

negative regulation of fat cell differentiation

3 references

14 February 2019

Inhibition of adipogenesis by Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Inhibition of adipogenesis by Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Regulation of osteoblastogenesis and bone mass by Wnt10b

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

positive regulation of protein phosphorylation

1 reference

14 February 2019

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

midbrain-hindbrain boundary maturation during brain development

1 reference

14 February 2019

Involvement of Wnt-1 in the formation of the mes/metencephalic boundary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

T cell differentiation in thymus

1 reference

14 February 2019

Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

spinal cord association neuron differentiation

1 reference

14 February 2019

Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

neuron fate determination

1 reference

14 February 2019

A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

central nervous system morphogenesis

1 reference

14 February 2019

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

positive regulation of canonical Wnt signaling pathway

1 reference

24 April 2018

Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04426&geneProductId=UniProtKB:P04426

negative regulation of cell differentiation

1 reference

14 February 2019

Control of dorsoventral somite patterning by Wnt-1 and beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

hematopoietic stem cell proliferation

1 reference

14 February 2019

A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

positive regulation of DNA-binding transcription factor activity

1 reference

14 February 2019

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

embryonic axis specification

1 reference

14 February 2019

int-1--a proto-oncogene involved in cell signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

negative regulation of transforming growth factor beta receptor signaling pathway

1 reference

14 February 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling

BMP signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development

ISO

cerebellum development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

ubiquitin-dependent SMAD protein catabolic process

1 reference

14 February 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

1 reference

14 February 2019

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

multicellular organism development

positive regulation of transcription, DNA-templated

2 references

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

WNT7a induces E-cadherin in lung cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

A role for WNT proteins in induction of dermomyotome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon

diencephalon development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

branching involved in ureteric bud morphogenesis

1 reference

14 February 2019

Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

midbrain-hindbrain boundary development

1 reference

14 February 2019

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

cellular response to peptide hormone stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

embryonic brain development

1 reference

14 February 2019

Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh.

inner ear morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

animal organ morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

negative regulation of ubiquitin-dependent protein catabolic process

TAS

1 reference

14 February 2019

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo

neuron fate commitment

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

3 references

Spemann organizer formation

1 reference

14 February 2019

Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

4 references

14 February 2019

Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

positive regulation of transcription by RNA polymerase II

TAS

5 references

14 February 2019

Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation

1 reference

14 February 2019

Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

midbrain dopaminergic neuron differentiation

1 reference

14 February 2019

Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

astrocyte-dopaminergic neuron signaling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

regulation of transcription, DNA-templated

1 reference

14 February 2019

A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

positive regulation of cell population proliferation

TAS

4 references

14 February 2019

A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

canonical Wnt signaling pathway

16 references

14 February 2019

A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Insulin and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Inhibition of adipogenesis by Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

negative regulation of oxidative stress-induced neuron death

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

regulation of signaling receptor activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

Wnt signaling pathway

6 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04426&geneProductId=UniProtKB:P04426

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04426&geneProductId=UniProtKB:P04426

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04426&geneProductId=UniProtKB:P04426

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04426&geneProductId=UniProtKB:P04426

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04426&geneProductId=UniProtKB:P04426

24 April 2018

Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04426&geneProductId=UniProtKB:P04426

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04426&geneProductId=UniProtKB:P04426

Wnt signaling pathway

3 references

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04426&geneProductId=UniProtKB:P04426

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04426&geneProductId=UniProtKB:P04426

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

Wnt signaling pathway

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

IBA

neuron differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04426

Wnt protein, conserved site

IBA

has part(s)

1 reference

stated in

InterPro Release 71.0