SH2B adaptor protein 2 (Q21115598)

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mammalian protein found in Homo sapiens

SH2B adapter protein 2
adapter protein with pleckstrin homology and Src homology 2 domains
SH2 and PH domain-containing adapter protein APS
SH2B2

Language	Label	Description	Also known as
English	SH2B adaptor protein 2	mammalian protein found in Homo sapiens	SH2B adapter protein 2 adapter protein with pleckstrin homology and Src homology 2 domains SH2 and PH domain-containing adapter protein APS SH2B2

Statements

1 reference

13 November 2019

UniProt protein ID

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14492

PH-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14492

SH2B adapter protein 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14492

Phenylalanine zipper superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14492

pleckstrin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2B2, SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phenylalanine zipper, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

JAK pathway signal transduction adaptor activity

determination method

1 reference

21 June 2018

APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14492&geneProductId=UniProtKB:O14492

determination method

signaling adaptor activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

transmembrane receptor protein tyrosine kinase adaptor activity

determination method

1 reference

21 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14492&geneProductId=UniProtKB:O14492

determination method

identical protein binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

JAK pathway signal transduction adaptor activity

determination method

JAK pathway signal transduction adaptor activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

plasma membrane

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

8 April 2019

APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

biological process

insulin receptor signaling pathway

determination method

1 reference

24 April 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14492&geneProductId=UniProtKB:O14492

determination method

blood coagulation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

regulation of receptor signaling pathway via JAK-STAT

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

positive regulation of signal transduction

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

intracellular signal transduction

determination method

1 reference

24 April 2018

Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14492&geneProductId=UniProtKB:O14492

determination method

B-1 B cell homeostasis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

nervous system development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

cytokine-mediated signaling pathway

determination method

1 reference

21 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14492&geneProductId=UniProtKB:O14492

determination method

regulation of metabolic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

actin cytoskeleton organization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

regulation of Ras protein signal transduction

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

regulation of immune response

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

antigen receptor-mediated signaling pathway

determination method

1 reference

21 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14492&geneProductId=UniProtKB:O14492

determination method

brown fat cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

intracellular signal transduction

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

8 April 2019

Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14492

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000401883

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000401883

ENSP00000440273

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000440273

ENSP00000483034

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000483034

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

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Wikisource(0 entries)

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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