OS9 endoplasmic reticulum lectin (Q21110122)

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mammalian protein found in Homo sapiens

protein OS-9
erlectin 2
endoplasmic reticulum lectin 2
osteosarcoma amplified 9, endoplasmic reticulum lectin
OS9
amplified in osteosarcoma 9
osteosarcoma amplified 9, endoplasmic reticulum associated protein

Language	Label	Description	Also known as
English	OS9 endoplasmic reticulum lectin	mammalian protein found in Homo sapiens	protein OS-9 erlectin 2 endoplasmic reticulum lectin 2 osteosarcoma amplified 9, endoplasmic reticulum lectin OS9 amplified in osteosarcoma 9 osteosarcoma amplified 9, endoplasmic reticulum associated protein

Statements

1 reference

13 November 2019

UniProt protein ID

Mannose-6-phosphate receptor binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13438

auxiliary protein involved in transmembrane transport

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Protein OS9-like family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

carbohydrate binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

protein binding

determination method

8 references

8 April 2019

Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

8 April 2019

DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

8 April 2019

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

8 April 2019

OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

8 April 2019

Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

8 April 2019

IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

8 April 2019

Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

8 April 2019

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

protease binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

Hrd1p ubiquitin ligase complex

determination method

3 references

8 April 2019

Mammalian OS-9 is upregulated in response to endoplasmic reticulum stress and facilitates ubiquitination of misfolded glycoproteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

8 April 2019

Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

8 April 2019

SEL1L protein critically determines the stability of the HRD1-SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

endoplasmic reticulum lumen

determination method

5 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13438&geneProductId=UniProtKB:Q13438

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13438&geneProductId=UniProtKB:Q13438

determination method

24 April 2018

A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13438&geneProductId=UniProtKB:Q13438

determination method

24 April 2018

Mammalian OS-9 is upregulated in response to endoplasmic reticulum stress and facilitates ubiquitination of misfolded glycoproteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13438&geneProductId=UniProtKB:Q13438

determination method

24 April 2018

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13438&geneProductId=UniProtKB:Q13438

determination method

endoplasmic reticulum membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

endoplasmic reticulum quality control compartment

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

endoplasmic reticulum

determination method

endoplasmic reticulum lumen

determination method

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

8 April 2019

A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

8 April 2019

Mammalian OS-9 is upregulated in response to endoplasmic reticulum stress and facilitates ubiquitination of misfolded glycoproteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

8 April 2019

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

biological process

protein targeting

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

protein retention in ER lumen

determination method

1 reference

8 April 2019

A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

negative regulation of retrograde protein transport, ER to cytosol

determination method

1 reference

8 April 2019

Identification of ERAD components essential for dislocation of the null Hong Kong variant of α-1-antitrypsin (NHK)

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

protein ubiquitination

determination method

1 reference

8 April 2019

Mammalian OS-9 is upregulated in response to endoplasmic reticulum stress and facilitates ubiquitination of misfolded glycoproteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

ubiquitin-dependent ERAD pathway

determination method

3 references

24 April 2018

A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13438&geneProductId=UniProtKB:Q13438

determination method

24 April 2018

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13438&geneProductId=UniProtKB:Q13438

determination method

24 April 2018

Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13438&geneProductId=UniProtKB:Q13438

determination method

response to endoplasmic reticulum stress

determination method

1 reference

8 April 2019

Mammalian OS-9 is upregulated in response to endoplasmic reticulum stress and facilitates ubiquitination of misfolded glycoproteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

endoplasmic reticulum mannose trimming

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

transmembrane transport

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

ubiquitin-dependent protein catabolic process

determination method

1 reference

8 April 2019

Mammalian OS-9 is upregulated in response to endoplasmic reticulum stress and facilitates ubiquitination of misfolded glycoproteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

ubiquitin-dependent ERAD pathway

determination method

4 references

8 April 2019

A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

8 April 2019

Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

8 April 2019

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

retrograde protein transport, ER to cytosol

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13438

determination method

Protein OS9-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13438

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000257966

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000257966

ENSP00000318165

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000318165

ENSP00000373794

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000373794

ENSP00000373798

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000373798

ENSP00000389632

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000389632

ENSP00000407360

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000407360

ENSP00000447866

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000447866

ENSP00000450010

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450010

ENSP00000413112

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000413112

ENSP00000447031

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000447031

ENSP00000447163

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000447163

ENSP00000447451

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000447451

ENSP00000447719

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000447719

ENSP00000448478

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000448478

ENSP00000449789

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000449789

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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