Bone morphogenetic protein receptor type 2 (Q21106712)

bone morphogenetic protein receptor type-2

1 reference

activin types I and II receptor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

transmembrane receptor protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

1 reference

8 April 2019

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

1 reference

8 April 2019

activin receptor activity, type II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

1 reference

8 April 2019

TAS

BMP binding

1 reference

8 April 2019

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

1 reference

8 April 2019

protein binding

7 references

8 April 2019

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

8 April 2019

Novel crosstalk to BMP signalling: cGMP-dependent kinase I modulates BMP receptor and Smad activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

8 April 2019

Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

8 April 2019

Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

8 April 2019

Dynamics and interaction of caveolin-1 isoforms with BMP-receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

8 April 2019

Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

8 April 2019

Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

1 reference

8 April 2019

growth factor binding

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13873&geneProductId=UniProtKB:Q13873

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

1 reference

8 April 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

1 reference

8 April 2019

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

1 reference

8 April 2019

transforming growth factor beta-activated receptor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

transforming growth factor beta receptor activity, type II

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

SMAD binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

BMP receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

1 reference

8 April 2019

spanning component of plasma membrane

TAS

1 reference

8 April 2019

Bone morphogenetic protein signaling is required for maintenance of differentiated phenotype, control of proliferation, and hypertrophy in chondrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

TAS

dendrite

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

soma

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

cell surface

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

integral component of plasma membrane

1 reference

26 September 2017

Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13873&geneProductId=UniProtKB:Q13873

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

8 April 2019

Functional changes in pulmonary arterial endothelial cells associated with BMPR2 mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

8 April 2019

8 April 2019

Dynamics and interaction of caveolin-1 isoforms with BMP-receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

basal plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

apical plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

extracellular space

1 reference

26 September 2017

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13873&geneProductId=UniProtKB:Q13873

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

1 reference

8 April 2019

postsynaptic density

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

extracellular space

HDA

1 reference

8 April 2019

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

integral component of plasma membrane

HDA

receptor complex

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

endothelial cell apoptotic process

biological process

1 reference

8 April 2019

Functional changes in pulmonary arterial endothelial cells associated with BMPR2 mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

positive regulation of epithelial cell migration

1 reference

8 April 2019

The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

positive regulation of endothelial cell proliferation

1 reference

8 April 2019

Regulation of bone morphogenetic protein signalling in human pulmonary vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

endochondral bone morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

1 reference

8 April 2019

positive regulation of endothelial cell migration

1 reference

8 April 2019

Regulation of bone morphogenetic protein signalling in human pulmonary vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

positive regulation of pathway-restricted SMAD protein phosphorylation

regulation of cell population proliferation

1 reference

8 April 2019

Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

negative regulation of cell growth

1 reference

8 April 2019

The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

transcription by RNA polymerase II

1 reference

8 April 2019

Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

regulation of lung blood pressure

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

8 April 2019

A novel mutation in the BMPR2 gene in familial pulmonary arterial hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

1 reference

8 April 2019

positive regulation of axon extension involved in axon guidance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

BMP signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

7 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

8 April 2019

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

8 April 2019

Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

8 April 2019

Bone morphogenetic protein signaling is required for maintenance of differentiated phenotype, control of proliferation, and hypertrophy in chondrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

8 April 2019

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

signal transduction

1 reference

26 September 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13873&geneProductId=UniProtKB:Q13873

proteoglycan biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

1 reference

8 April 2019

positive regulation of cartilage development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

1 reference

8 April 2019

maternal placenta development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

endothelial cell proliferation

1 reference

8 April 2019

Functional changes in pulmonary arterial endothelial cells associated with BMPR2 mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

cellular response to starvation

IEP

1 reference

8 April 2019

Dynamics and interaction of caveolin-1 isoforms with BMP-receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

negative regulation of DNA biosynthetic process

IEP

1 reference

8 April 2019

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

chondrocyte development

1 reference

8 April 2019

Bone morphogenetic protein signaling is required for maintenance of differentiated phenotype, control of proliferation, and hypertrophy in chondrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

negative regulation of systemic arterial blood pressure

1 reference

8 April 2019

A novel mutation in the BMPR2 gene in familial pulmonary arterial hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

positive regulation of osteoblast differentiation

1 reference

8 April 2019

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

cellular response to BMP stimulus

1 reference

8 April 2019

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

1 reference

8 April 2019

brain development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

retina development in camera-type eye

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

positive regulation of BMP signaling pathway

1 reference

8 April 2019

Regulation of bone morphogenetic protein signalling in human pulmonary vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

limb development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

positive regulation of bone mineralization

1 reference

8 April 2019

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

negative regulation of chondrocyte proliferation

1 reference

8 April 2019

Bone morphogenetic protein signaling is required for maintenance of differentiated phenotype, control of proliferation, and hypertrophy in chondrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

mitral valve morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

pharyngeal arch artery morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

tricuspid valve morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

outflow tract septum morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

atrioventricular valve morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

activin receptor signaling pathway

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

cardiac muscle tissue development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

positive regulation of transcription by RNA polymerase II

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

8 April 2019

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

transforming growth factor beta receptor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

pattern specification process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13873

http://purl.uniprot.org/uniprot/Q13873

exact match

1 reference

protein kinase, ATP binding site

Identifiers.org

has part(s)

1 reference

protein kinase domain

1 reference

activin types I and II receptor domain

1 reference